Evidence map›Paper›PMID 33494818›Full record

ArticleItalian journal of pediatrics2021

Management of pediatric post-infectious neurological syndromes.

Elena Bozzola, Giulia Spina, Massimiliano Valeriani, Laura Papetti, Fabiana Ursitti, Rino Agostiniani, Cristina Mascolo, Margherita Ruggiero, Chiara Di Camillo, Anna Quondamcarlo and 4 more

Abstract read
In one paragraph

Article in Italian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Viruses, parkinsonism and Parkinson's disease: the past, present and future.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elena BozzolaItalian Pediatric Society, Florence, Italy. elena.bozzola@opbg.net.ORCID http://orcid.org/0000-0003-2586-019X
Giulia SpinaItalian Pediatric Society, Florence, Italy.
Massimiliano ValerianiDepartment of Neuroscience, Headache Center, Bambino Gesù Children Hospital, Rome, Italy.
Laura PapettiDepartment of Neuroscience, Headache Center, Bambino Gesù Children Hospital, Rome, Italy.
Fabiana UrsittiDepartment of Neuroscience, Headache Center, Bambino Gesù Children Hospital, Rome, Italy.
Rino AgostinianiItalian Pediatric Society, Florence, Italy.
Cristina MascoloItalian Pediatric Society, Florence, Italy.
Margherita RuggieroUniversity of Tor Vergata, Rome, Italy.
Chiara Di CamilloItalian Pediatric Society, Florence, Italy.
Anna QuondamcarloItalian Pediatric Society, Florence, Italy.
Luigi MateraUniversity of Sapienza, Rome, Italy.
Davide VecchioItalian Pediatric Society, Florence, Italy.
Luigi MemoItalian Pediatric Society, Florence, Italy.
Alberto VillaniItalian Pediatric Society, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-Infectious Neurological Syndromes (PINS) are heterogeneous neurological disorders with post or para-infectious onset. PINS diagnosis is complex, mainly related to the absence of any recognized guidelines and a univocal definition. AIM OF THE STUDY: To elaborate a diagnostic guide for PINS. MATERIALS AND

methodsWe retrospectively analysed patients younger than 14 years old admitted to Bambino Gesù Children's Hospital in Rome for PINS from December 2005 to March 2018. Scientific literature using PubMed as research platform was analysed: the key words "Post-Infectious Neurological Syndromes" were used.

resultsA polysymptomatic presentation occurred in a percentage of 88% of the children. Motor signs and visual disturbances the most observed symptoms/signs were the most detached, followed by fever, speech disturbances, sleepiness, headache and bradipsychism. Blood investigations are compatible with inflammation, as a prodromal illnesses was documented in most cases. Normal cerebral spinal fluid (CSF) characteristics has been found in the majority of the study population. Magnetic resonance imaging (MRI) was positive for demyelinating lesions. Antibiotics, acyclovir and steroids have been given as treatment. DISCUSSION: We suggest diagnostic criteria for diagnosis of PINS, considering the following parameters: neurological symptoms, timing of disease onset, blood and CSF laboratory tests, MRI imaging.

conclusionsWe propose criteria to guide clinician to diagnose PINS as definitive, probable or possible. Further studies are required to validate diagnostic criteria.

Indexed as

AdolescentAnti-Infective AgentsBiomarkersChildDemyelinating DiseasesDiagnosis, DifferentialHumansInfectionsMagnetic Resonance ImagingMaleRetrospective StudiesSteroidsSyndromeAnti-Infective AgentsBiomarkersSteroidsAcute demyelinating syndromesChildrenPost-infectious neurological syndromes

Identifiers

PMID33494818
PMCPMC7836589

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.