Evidence map›Paper›PMID 33494777›Full record

ReviewParasites & vectors2021

Behavioral biology of Toxoplasma gondii infection.

Wen Han Tong, Chris Pavey, Ryan O'Handley, Ajai Vyas

Open access · goldAbstract readReview
In one paragraph

Review in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Delayed Pathogenicity inMicroorganisms · 2026
    Article
  6. Antimicrobial agents and chemotherapy · 2026
    Article
  7. Photodynamic Therapy for Toxoplasma gondii Infections Using Rose Bengal.Luminescence : the journal of biological and chemical luminescence · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Coinfection ofFrontiers in immunology · 2026
    Article
  15. Toxoplasma gondii and the Brain: Frenemies? Or Just Outright Foes?Journal of the Pediatric Infectious Diseases Society · 2025
    Review
  16. Review
  17. Article
  18. Beyond Latency: ChronicBiomedicines · 2025
    Review
  19. PCR Detection, Genotyping, and Differentiation ofPathogens (Basel, Switzerland) · 2025
    Article
  20. Microorganisms · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Wen Han TongSchool of Biological Sciences, Nanyang Technological University (SBS-NTU), 60 Nanyang Drive, Singapore, 637551, Singapore.
Chris PaveyCommonwealth Scientific and Industrial Research Organisation (CSIRO) Land and Water, Darwin, Australia.
Ryan O'HandleySchool of Animal and Veterinary Sciences, University of Adelaide, Roseworthy Campus, Roseworthy, Australia.
Ajai VyasSchool of Biological Sciences, Nanyang Technological University (SBS-NTU), 60 Nanyang Drive, Singapore, 637551, Singapore. avyas@ntu.edu.sg.ORCID http://orcid.org/0000-0002-2592-6796
Nanyang Technological University · SGCSIRO Land and Water · AUThe University of Adelaide · AU

Funding

Human Frontier Science Program RGP0062/2018
6 · The paper itself

Abstract

Toxoplasma gondii is a protozoan parasite with a complex life cycle and a cosmopolitan host range. The asexual part of its life cycle can be perpetually sustained in a variety of intermediate hosts through a combination of carnivory and vertical transmission. However, T. gondii produces gametes only in felids after the predation of infected intermediate hosts. The parasite changes the behavior of its intermediate hosts by reducing their innate fear to cat odors and thereby plausibly increasing the probability that the definitive host will devour the infected host. Here, we provide a short description of such parasitic behavioral manipulation in laboratory rodents infected with T. gondii, along with a bird's eye view of underpinning biological changes in the host. We also summarize critical gaps and opportunities for future research in this exciting research area with broad implications in the transdisciplinary study of host-parasite relationships.

Indexed as

Behavior, AnimalHost-Parasite InteractionsToxoplasmaAnimalsCatsFearHumansLife Cycle StagesOdorantsRodentiaToxoplasmosis, AnimalApicomplexaBehavioral manipulationComplex life cycleExtended phenotypesParasitic manipulationProtozoa

Identifiers

PMID33494777
PMCPMC7831251
OpenAlexW3123199762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.