ReviewJournal of the American Heart Association2021
Noncalcific Mechanisms of Bioprosthetic Structural Valve Degeneration.
Review in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Pyriphenone modification of glutaraldehyde pretreated bovine pericardium mitigates advanced glycation end products, calcification, and platelet adhesion.Acta biomaterialia · 2026Article
- Biofabrication strategies for engineered constructs in cardiovascular tissue repair.Regenerative therapy · 2026Review
- A Parametric Finite Element Analysis of Chick Embryo Aortic Valve Leaflet Biomechanics.Bioengineering (Basel, Switzerland) · 2026Article
- Antibody and Cellular Immune Responses in Old α1,3-Galactosyltransferase-Knockout Mice Implanted with Bioprosthetic Heart Valve Tissues.Bioengineering (Basel, Switzerland) · 2025Article
- A custom preservation solution extends the ex vivo availability of living heart valves for transplantation.JTCVS open · 2025Article
- Valve-in-Valve Transcatheter Aortic Valve Implantation Versus Redo SAVR for Degenerated Biological Prosthesis: A Narrative Review Stating Our Experience.Journal of clinical medicine · 2025Review
- Mechanistic Insights into Bioprosthetic Heart Valve Calcification and Anti-Calcification Strategies.Reviews in cardiovascular medicine · 2025Review
- [Structural valve deterioration after transcatheter aortic valve replacement: a research update].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Review
- Structural valve deterioration is primarily caused by cyclic fatigue but not immune rejection.Frontiers in immunology · 2025Article
- Inflammatory biomarkers as predictors of prognosis in patients after transcatheter aortic valve implantation.Frontiers in cardiovascular medicine · 2025Article
- Single center experience with surgically implanted Melody and Sapien 3 valves in the mitral position in young children.Frontiers in cardiovascular medicine · 2025Article
- Contemporary Multi-modality Imaging of Prosthetic Aortic Valves.Reviews in cardiovascular medicine · 2025Review
- Who Lives Longer, the Valve or the Patient? The Dilemma of TAVI Durability and How to Optimize Patient Outcomes.Journal of clinical medicine · 2024Review
- Article
- Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Recent progress in functional modification and crosslinking of bioprosthetic heart valves.Regenerative biomaterials · 2024Review
- Treatment of Severe Pulmonary Regurgitation in Enlarged Native Right Ventricular Outflow Tracts: Transcatheter Pulmonary Valve Replacement with Three-Dimensional Printing Guidance.Bioengineering (Basel, Switzerland) · 2023Article
- Pediatric pulmonary valve replacements: Clinical challenges and emerging technologies.Bioengineering & translational medicine · 2023Review
- Article
- Age-related enhanced degeneration of bioprosthetic valves due to leaflet calcification, tissue crosslinking, and structural changes.Cardiovascular research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Bioprosthetic heart valves (BHVs) largely circumvent the need for long-term anticoagulation compared with mechanical valves but are increasingly susceptible to deterioration and reduced durability with reoperation rates of ≈10% and 30% at 10 and 15 years, respectively. Structural valve degeneration is a common, unpreventable, and untreatable consequence of BHV implantation and is frequently characterized by leaflet calcification. However, 25% of BHV reoperations attributed to structural valve degeneration occur with minimal leaflet mineralization. This review discusses the noncalcific mechanisms of BHV structural valve degeneration, highlighting the putative roles and pathophysiological relationships between protein infiltration, glycation, oxidative and mechanical stress, and inflammation and the structural consequences for surgical and transcatheter BHVs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.