ArticleDiagnostics (Basel, Switzerland)2021
Aging and Allostasis: Using Bayesian Network Analytics to Explore and Evaluate Allostatic Markers in the Context of Aging.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Allostatic load index across the psychosis spectrum: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Th1/Th2 immune regulation and functional resilience in older adults following severe COVID-19: a prospective cohort study.European geriatric medicine · 2026Article
- Review
- Prehabilitation: A Catalyst for Transforming Toward Value-Based, Personalized Perioperative Health and Care.Journal of clinical medicine · 2025Article
- Allostatic load, a measure of cumulative physiological stress, impairs brain structure but notFrontiers in aging neuroscience · 2025Article
- The gender and age perspectives of allostatic load.Frontiers in medicine · 2024Review
- Features of Allostatic Load in Patients with Essential Hypertension without Metabolic Syndrome Depending on the Nature of Nighttime Decreases in Blood Pressure.Diagnostics (Basel, Switzerland) · 2023Article
- Review
- Allostatic load as predictor of mortality: a cohort study from Lolland-Falster, Denmark.BMJ open · 2022Article
- Neutralizing a Springboard for Inflammation: Physical Activity to Control the Immune Network.Healthcare (Basel, Switzerland) · 2021Article
- The Applicability of the Poincaré Plot in the Analysis of Variability of Reaction Time during Serial Testing.International journal of environmental research and public health · 2021Observational
- Physical activity attenuates the association between allostatic load and early Alzheimer's disease-related biomarkers in older adults.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Allostatic load reflects the cumulative strain on organic functions that may gradually evolve into overt disease. Our aim was to evaluate the allostatic parameters in the context of aging, and identify the parameters that may be suitable for an allostatic load index for elderly people (>60 years). From previously published studies, 11 allostatic (bio)markers could be identified that sustain sufficient variability with aging to capture meaningful changes in health status. Based on reported statistics (prevalence of a biomarker and its associated outcome, and/or an odds/risk ratio relating these two), seven of these could be adopted in a Bayesian Belief Network (BBN), providing the probability of "disturbed" allostasis in any given elder. Additional statistical analyses showed that changes in IL-6 and BMI contributed the most to a "disturbed" allostasis, indicating their prognostic potential in relation to deteriorating health in otherwise generally healthy elderly. In this way, and despite the natural decline in variance that irrevocably alters the prognostic relevance of most allostatic (bio)markers with aging, it appeared possible to outline an allostatic load index specifically for the elderly. The allostatic parameters here identified might consequently be considered a useful basis for future quantitative modelling in the context of (healthy) aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.