ReviewJournal of clinical medicine2021
Risk Factors of Intervertebral Disc Pathology-A Point of View Formerly and Today-A Review.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association ofMedicina (Kaunas, Lithuania) · 2025Pooled it
- Article
- Application of GBD 2021 and multiple omics to reveal the association and potential mechanism between glycated hemoglobin and intervertebral disc degeneration.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Development and validation of a prognostic prediction model for lumbar-disc herniation based on machine learning and fusion of clinical text data and radiomic features.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Lipids and Lipid-Lowering Drugs With Risk of Intervertebral Disc Degeneration: A Mendelian Randomization Study.Genetics research · 2026Article
- Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits.Medicine · 2025Article
- A Systematic Review and Meta-Analysis of Preoperative Characteristics and Postoperative Outcomes in Patients Undergoing Endoscopic Spine Surgery: Part I Endoscopic Microdiscectomy.Journal of clinical medicine · 2025Review
- Targeting FABP4 to Inhibit AGEs-RAGE/NF-κB Signalling Effectively Ameliorates Nucleus Pulposus Dysfunction and Angiogenesis in Obesity-Related Intervertebral Disc Degeneration.Cell proliferation · 2025Article
- Adolescent lumbar disc herniation: etiology, diagnosis, and treatment options.Journal of orthopaedic surgery and research · 2025Review
- Histopathologic degenerative score as a predictor of minimal clinically important difference in pain and functionality following surgical treatment for disc herniation.Biomolecules & biomedicine · 2025Observational
- Multifidus fat infiltration negatively influences the postoperative outcomes in lumbar disc herniation following transforaminal approach percutaneous endoscopic lumbar discectomy.European journal of medical research · 2025Article
- A Primer on Anatomy, Biophysics, Pathology, Imaging and Treatment of the Intervertebral Disc and the Anterior Spinal Column: The Discogenic, Intervertebral, Spinal Column (DISC) ASPN Workgroup.Journal of pain research · 2025Article
- Article
- Article
- Ultrasound-Guided Cervical Selective Nerve Root Block versus Fluoroscopy-Guided Interlaminar Epidural Injection for Cervical Radicular Pain: A Randomized, Prospective, Controlled Study.Journal of personalized medicine · 2024Article
- Risk Factors for Surgical Treatment of Lumbar Degenerative Disc Disease in Middle-aged and Older Women: A Prospective Case-Control Study of 2370 Subjects.Orthopaedic surgery · 2024Article
- Thoracic Intervertebral Disc Herniation Associated With Chronic Anabolic Androgenic Steroid Use: A Case Report.Cureus · 2024Article
- Plain Radiography: A Unique Component of Spinal Assessment and Predictive Health.Healthcare (Basel, Switzerland) · 2024Review
- Genetic predisposition ofCell cycle (Georgetown, Tex.) · 2024Article
- Effect of two-level decompressive procedures on the biomechanics of the lumbo-sacral spine: anFrontiers in bioengineering and biotechnology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intervertebral disc pathology is a common disorder that can be caused by genetic, mechanical, and behavioral factors; however, it is possible to slow its progression. Although environmental and behavioral factors were previously considered to be the sole causes of intervertebral disc pathologies such as disc herniation, recent studies have shown that genetic factors also play an important role. This review compares the perception of major risk factors from the last and present centuries. It also examines individual genetic and non-genetic factors acting as risk factors, as well as some approaches for preventing intervertebral disc pathologies, and compares available statistics regarding disc herniation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.