Evidence map›Paper›PMID 33494350›Full record

ArticleAnimals : an open access journal from MDPI2021

Concentration-Dependent Type 1 Interferon-Induced Regulation of MX1 and FABP3 in Bovine Endometrial Explants.

Simone Tamara Schabmeyer, Anna Maria Kneidl, Julia Katharina Schneider, Sandra Kirsch, Yury Zablotski, Wolfram Petzl, Frank Weber, Holm Zerbe, Marie Margarete Meyerholz

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Simone Tamara SchabmeyerClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine Ludwig Maximilians University Munich, 85764 Oberschleissheim, Germany.
Anna Maria KneidlClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine Ludwig Maximilians University Munich, 85764 Oberschleissheim, Germany.
Julia Katharina SchneiderClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine Ludwig Maximilians University Munich, 85764 Oberschleissheim, Germany.
Sandra KirschClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine Ludwig Maximilians University Munich, 85764 Oberschleissheim, Germany.
Yury ZablotskiClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine Ludwig Maximilians University Munich, 85764 Oberschleissheim, Germany.
Wolfram PetzlClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine Ludwig Maximilians University Munich, 85764 Oberschleissheim, Germany.
Frank WeberClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine Ludwig Maximilians University Munich, 85764 Oberschleissheim, Germany.
Holm ZerbeClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine Ludwig Maximilians University Munich, 85764 Oberschleissheim, Germany.ORCID 0000-0002-7972-4858
Marie Margarete MeyerholzClinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine Ludwig Maximilians University Munich, 85764 Oberschleissheim, Germany.
Ludwig-Maximilians-Universität München · DE

Funding

Ludwig-Maximilians-Universität München Faculty of Veterinary Medicine, 08LMU Mentoring Program for Young Scientists and VET Research Program 2018, 2019 and 2020
6 · The paper itself

Abstract

The inadequate maternal recognition of embryonic interferon τ (IFNτ) might explain subfertility in cattle. This study aimed at modeling the inducibility of type 1 interferon receptor subunits 1/2 (IFNAR1/2), mimicking competition between IFNτ and infection-associated interferon α (IFNα), and simulating type 1 interferon pathways in vitro. Endometrial explants (n = 728 from n = 26 healthy uteri) were collected at the abattoir, challenged with IFNτ and/or IFNα in different concentrations, and incubated for 24 h. Gene expression analysis confirmed the inducibility of IFNAR1/2 within this model, it being most prominent in IFNAR2 with 10 ng/mL IFNα (

Indexed as

3R principlecattleembryo–maternal communicationendometrial explant modelinterferon stimulated gene (ISG)interferon αinterferon τsubfertilitytype 1 interferon receptor subunits 1/2 (IFNAR1/2)type 1 interferon signaling

Identifiers

PMID33494350
PMCPMC7912598
OpenAlexW3124734033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.