ArticleInternational journal of molecular sciences2021
Magnesium Deficiency Induces Lipid Accumulation in Vascular Endothelial Cells via Oxidative Stress-The Potential Contribution of EDF-1 and PPARγ.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- The association between magnesium and diabetic retinopathy: a cross-sectional study.BMC ophthalmology · 2026Article
- Magnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.Nutrients · 2026Review
- Association of low magnesium status with incident intracranial hemorrhage: a matched-control database study.Frontiers in nutrition · 2026Article
- Bioceramic bone tissue-engineered substitutes with anti-inflammatory effects in periodontitis.Frontiers in bioengineering and biotechnology · 2026Review
- Article
- Ex Vivo Plasma Application on Human Brain Microvascular Endothelial-like Cells for Blood-Brain Barrier Modeling.International journal of molecular sciences · 2025Article
- EDF1 accelerates ganglioside GD3 accumulation to boost CD52-mediated CD8Journal of experimental & clinical cancer research : CR · 2025Article
- Association between magnesium depletion score and periodontitis in US adults: results from NHANES 2009-2014.BMC oral health · 2024Article
- Effect of High Magnesium and Astragaloside IV on Vascular Endothelial Cells.Cell biochemistry and biophysics · 2024Article
- Impact of Inducible Nitric Oxide Synthase Activation on Endothelial Behavior under Magnesium Deficiency.Nutrients · 2024Article
- Magnesium and the Hallmarks of Aging.Nutrients · 2024Review
- Associations between nine dietary minerals intake and all-cause mortality in individuals with atherosclerotic cardiovascular disease.Frontiers in nutrition · 2024Article
- Magnesium Deficiency and Cardiometabolic Disease.Nutrients · 2023Review
- The Role of Txnip in Mediating Low-Magnesium-Driven Endothelial Dysfunction.International journal of molecular sciences · 2023Article
- The Interplay between TRPM7 and MagT1 in Maintaining Endothelial Magnesium Homeostasis.Membranes · 2023Article
- The Effects of Sirolimus and Magnesium on Primary Human Coronary Endothelial Cells: An In Vitro Study.International journal of molecular sciences · 2023Article
- Magnesium ions improve vasomotor function in exhausted rats.PloS one · 2023Article
- Review
- Comparative Efficacy of Antihypertensive Agents in Flow-Mediated Vasodilation of Patients with Hypertension: Network Meta-Analysis of Randomized Controlled Trial.International journal of hypertension · 2022Review
- Quantitative proteomics on the cerebrospinal fluid of hydrocephalus in neonatal bacterial meningitis.Frontiers in pediatrics · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMagnesium deficiency contributes to atherogenesis partly by promoting the dysfunction of endothelial cells, which are critical in vascular homeostasis and diseases. Since EDF-1 and PPARγ regulate crucial endothelial activities, we investigated the modulation of these proteins involved in lipogenesis as well the deposition of lipids in human endothelial cells cultured in different concentrations of magnesium.
methodsHuman endothelial cells from the umbilical vein were cultured in medium containing from 0.1 to 5 mM magnesium for 24 h. The levels of EDF-1 and PPARγ were visualized by Western blot. Reactive oxygen species (ROS) were measured by DCFDA. Lipids were detected after O Red Oil staining.
resultsMagnesium deficiency leads to the accumulation of ROS which upregulate EDF-1. Further, PPARγ is increased after culture in low magnesium, but independently from ROS. Moreover, lipids accumulate in magnesium-deficient cells.
conclusionsOur results suggest that magnesium deficiency leads to the deposition of lipids by inducing EDF-1 and PPARγ. The increase in intracellular lipids might be interpreted as an adaptive response of endothelial cells to magnesium deficiency.
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