Evidence map›Paper›PMID 33494277›Full record

ReviewNutrients2021

Illuminating the Role of Vitamin A in Skin Innate Immunity and the Skin Microbiome: A Narrative Review.

Fritzlaine C Roche, Tamia A Harris-Tryon

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07580846 (AssessmenT of thE Adherence of Nutritional Supplementation With Creatine Formula in Estrogen-Depleted Adult Women), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07580846 recruitingnot on this mapstarted 2026, after this paper: background citation

AssessmenT of thE Adherence of Nutritional Supplementation With Creatine Formula in Estrogen-Depleted Adult Women: Prospective Clinical Investigation

TypeobservationalSponsorMargan BiotechRan2026 to 2026Enrolled100ConditionsMenopause, Estrogen Deficiency
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Frontiers in pharmacology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Pet Wellness and Vitamin A: A Narrative Overview.Animals : an open access journal from MDPI · 2024
    Review
  17. Article
  18. Review
  19. Review
  20. Viruses and autism: A Bi-mutual cause and effect.World journal of virology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Fritzlaine C RocheDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Tamia A Harris-TryonDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
The University of Texas Southwestern Medical Center · USUniversity of Rochester · US

Funding

Dermatology Foundation Diversity Research Supplement Award
6 · The paper itself

Abstract

Vitamin A is a fat-soluble vitamin that plays an important role in skin immunity. Deficiencies in Vitamin A have been linked to impaired immune response and increased susceptibility to skin infections and inflammatory skin disease. This narrative review summarizes recent primary evidence that elucidates the role of vitamin A and its derivatives on innate immune regulators through mechanisms that promote skin immunity and sustain the skin microbiome.

Indexed as

Immunity, InnateAnimalsDermatitisHumansMicrobiotaSkinStaphylococcus aureusTretinoinVitamin AVitamin A DeficiencyTretinoinVitamin Ainnate immunityretinoic acidskin immunityskin microbiomevitamin A

Identifiers

PMID33494277
PMCPMC7909803
OpenAlexW3121870850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.