ArticleJournal of pathology and translational medicine2021
A study of pathological characteristics and BRAF V600E status in Langerhans cell histiocytosis of Vietnamese children.
Article in Journal of pathology and translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Langerhans cell histiocytosis: molecular mechanisms underlying pathogenesis and emerging targeted therapeutics.Cancer metastasis reviews · 2026Review
- When Skin-Limited Langerhans Cell Histiocytosis Becomes Life-Threatening: Severe Treatment-Related Morbidity in a Prematurely Born Infant-Case Report.Reports (MDPI) · 2026Article
- Pathologic characteristics of histiocytic and dendritic cell neoplasms.Blood research · 2024Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLangerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH.
methodsWe collected paraffin blocks of 94 pediatric LCH patients to detect BRAF V600E mutation by sequencing. The relationship between BRAF V600E status and clinicopathological parameters were also critically analyzed.
resultsBRAF V600E mutation exon 15 was detected in 45 cases (47.9%). Multiple systems LCH showed a significantly higher BRAF V600E mutation rate than a single system (p=.001). No statistical significance was evident for other clinical characteristics such as age, sex, location, risk organs involvement, and CD1a expression.
conclusionsIn Vietnamese LCH children, the proportion of BRAF V600E mutational status was relatively high and related to multiple systems.
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Registered trials
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