Evidence map›Paper›PMID 33494069›Full record

ArticleAging2021

LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson's disease progression.

Qian Zhou, Ming-Ming Zhang, Min Liu, Zhi-Gang Tan, Qi-Lin Qin, Yu-Gang Jiang

Open access · greenAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Unlocking Parkinson's disease: the role of microRNAs in regulation, diagnosis, and therapy.Apoptosis : an international journal on programmed cell death · 2025
    Review
  9. Article
  10. Review
  11. LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review.Cellular and molecular neurobiology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Long Non-Coding RNAs: New Insights in Neurodegenerative Diseases.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Article
  20. Longitudinal dysregulation of long non-coding RNAs in Parkinson's disease.Experimental biology and medicine (Maywood, N.J.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qian ZhouDepartment of Neurosurgery, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, P.R. China.
Ming-Ming ZhangDepartment of Neurosurgery, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, P.R. China.
Min LiuDepartment of Neurosurgery, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, P.R. China.
Zhi-Gang TanDepartment of Neurosurgery, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, P.R. China.
Qi-Lin QinDepartment of Neurosurgery, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, P.R. China.
Yu-Gang JiangDepartment of Neurosurgery, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, P.R. China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

1-Methyl-4-phenylpyridiniumAnimalsApoptosisCarrier ProteinsCell Line, TumorDisease ProgressionGene Knockdown TechniquesHerbicidesHumansIntracellular Signaling Peptides and ProteinsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MiceMicroRNAsNerve Tissue ProteinsNeuronsParkinson Disease1-Methyl-4-phenylpyridiniumCarrier ProteinsHerbicidesIntracellular Signaling Peptides and ProteinsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MicroRNAsmirn199 microRNA, humanMirn199 microRNA, mouseMIRN199 microRNA, ratNerve Tissue ProteinsRNA, Long NoncodingSNCAIP protein, humanSncaip protein, mouseSncaip protein, ratXIST non-coding RNAlncRNA XISTLRRK2miR-199a-3pParkinson's diseaseSp1

Identifiers

PMID33494069
PMCPMC7906184
OpenAlexW3121298662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.