Evidence map›Paper›PMID 33493493›Full record

ArticleThe Journal of pediatrics2021

Many Young Children with Autism Who Use Psychotropic Medication Do Not Receive Behavior Therapy: A Multisite Case-Control Study.

Lisa D Wiggins, Cy Nadler, Steven Rosenberg, Eric Moody, Nuri Reyes, Ann Reynolds, Aimee Alexander, Julie Daniels, Kathleen Thomas, Ellen Giarelli and 1 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Lisa D WigginsNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address: lwiggins@cdc.gov.
Cy NadlerSchool of Medicine, University of Missouri - Kansas City, Kansas City, MO.
Steven RosenbergSchool of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO.
Eric MoodyInstitute for Disabilities, University of Wyoming, Laramie, WY.
Nuri ReyesSchool of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO.
Ann ReynoldsSchool of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO.
Aimee AlexanderNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA.
Julie DanielsDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC.
Kathleen ThomasCenter for Health Services Research, University of North Carolina, Chapel Hill, NC.
Ellen GiarelliCollege of Nursing and Health Professions, Drexel University, Philadelphia, PA.
Susan E LevyCenter for Autism Research, Children's Hospital of Philadelphia, Philadelphia, PA.
University of Colorado Anschutz Medical Campus · USCenters for Disease Control and Prevention · USUniversity of North Carolina at Chapel Hill · USChildren's Hospital of Philadelphia · USDrexel University · USUniversity of Missouri–Kansas City · USUniversity of Wyoming · US

Funding

NC CADDRE: Study to Explore Early Development (SEED) Phase IIU01DD000749 · DD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANIELS, JULIE L · 2011 to 2015
$5.0M
California CADDRE-SEED Phase IIU01DD000748 · DD · KAISER FOUNDATION RESEARCH INSTITUTE · PI CROEN, LISA A · 2011 to 2015
$5.0M
Data Coordinating Center for Autism & Other Developmental Disabilities: SEED I&IIU10DD000901 · DD · MICHIGAN STATE UNIVERSITY · PI REED, PHILIP L · 2012 to 2015
$3.5M
Patient-Level Meta-analysis: Effect of age of initiation, intensity and durationU01DD000757 · DD · UNIVERSITY OF COLORADO DENVER · PI MANCO-JOHNSON, MARILYN J · 2011 to 2013
$590k
ACL HHS U01DD000746ACL HHS U01DD000750ACL HHS U01DD001216Intramural CDC HHS CC999999NCBDD CDC HHS U01 DD000746NCBDD CDC HHS U01 DD000748NCBDD CDC HHS U01 DD000749NCBDD CDC HHS U01 DD000750NCBDD CDC HHS U01 DD000757NCBDD CDC HHS U01 DD001210NCBDD CDC HHS U01 DD001216NCBDD CDC HHS U10 DD000901
6 · The paper itself

Abstract

objectivesTo explore how many pre-school aged children with autism spectrum disorder (ASD) used psychotropic medication, child and geographic factors associated with psychotropic medication use, and how many children who used psychotropic medication did or did not ever receive behavior therapy. STUDY

designChildren 2-5 years of age were enrolled from 2012 to 2016 in a multisite case-control study designed to investigate the development and risk factors of ASD. Children with a positive ASD screen or ASD diagnosis upon enrollment were asked to complete a comprehensive evaluation to determine ASD status and developmental level. Caregivers completed a Services and Treatments Questionnaire and multiple self-administered questionnaires to determine child use of psychotropic medication, ever receipt of behavior therapy, and presence of co-occurring symptoms.

resultsThere were 763 children who were classified as ASD and had data collected on the Services and Treatments Questionnaire. Of those, 62 (8.1%) used psychotropic medication to treat behavioral symptoms and 28 (3.7%) were ≤3 years of age when medication was first started. Attention problems (aOR, 7.65; 95% CI, 3.41-16.1; P < .001) and study site (aOR, 2.62; 95% CI, 1.04-6.56; P = .04) were significantly associated with psychotropic medication use after controlling for maternal race/ethnicity. More than one-half (59.7%) of those who used psychotropic medication did not ever receive behavior therapy.

conclusionsMany preschool-aged children with ASD who use psychotropic medication do not receive behavior therapy. Pediatricians are an important resource for children and families and can help facilitate behavioral treatment for children with ASD and other disorders.

Indexed as

Autism Spectrum DisorderBehavior TherapyCase-Control StudiesChild, PreschoolCombined Modality TherapyDrug UtilizationFemaleHealth Care SurveysHealth Services AccessibilityHumansMalePractice Patterns, Physicians'Psychotropic DrugsTreatment OutcomeUnited StatesPsychotropic Drugs

Identifiers

PMID33493493
PMCPMC8174527
OpenAlexW3123699654

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.