Evidence map›Paper›PMID 33493428›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Microbiota, Epigenetics, and Trained Immunity. Convergent Drivers and Mediators of the Asthma Trajectory from Pregnancy to Childhood.

Susan V Lynch, Donata Vercelli

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Asthma: Biomedical and Psychobiological Perspectives.Biopsychosocial science and medicine · 2025
    Review
  5. Review
  6. Indoor bioaerosols and asthma: Overview, implications, and mitigation strategies.The Journal of allergy and clinical immunology · 2025
    Review
  7. Review
  8. Review
  9. Gut microbiome in the first 1000 days and risk for childhood food allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Review
  10. Article
  11. Review
  12. [Latest Findings on the Effect of Gastrointestinal Microecology Remodeling of Tumor Microenvironment on Tumor Stemness].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Review
  13. Article
  14. Article
  15. The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Review
  16. Microbiome-Immune Interactions in Allergy and Asthma.The journal of allergy and clinical immunology. In practice · 2022
    Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Susan V LynchDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, California; and.
Donata VercelliDepartment of Cellular and Molecular Medicine & Asthma and Airway Disease Research Center, University of Arizona, Tucson, Arizona.
University of Arizona · USUniversity of California, San Francisco · US

Funding

Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
The Effect of Dog-Keeping and the Intestinal Microbiota on Immune DevelopmentP01AI089473 · NIAID · HENRY FORD HEALTH SYSTEM · PI JOHNSON, CHRISTINE C · 2012 to 2024
$25.7M
Wisconsin Infant Study Cohort (WISC)U19AI104317 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, CHRISTINE Marie SEROOGY · 2013 to 2026
$22.5M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUG3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2016 to 2024
$19.3M
Recruitment, Data Collection & Sample Management CoreP01AI148104 · NIAID · UNIVERSITY OF ARIZONA · PI Tara F Carr, Susan Veronica Lynch · 2020 to 2026
$19.0M
Role of Gamma delta-17 T Cells in Asthma Protection by Amish Farm Exposure .R21AI144722 · NIAID · UNIVERSITY OF ARIZONA · PI VERCELLI, DONATA · 2019 to 2020
$443k
Interactions between Environmental Microbiome, Maternal Immunity, Neonatal Epigenome and Respiratory Microbiome Development as Determinants of Asthma In ChildhoodR21AI133765 · NIAID · UNIVERSITY OF ARIZONA · PI LYNCH, SUSAN VERONICA, VERCELLI, DONATA · 2017 to 2018
$439k
NIAID NIH HHS P01 AI089473NIAID NIH HHS P01 AI148104NIAID NIH HHS R21 AI133765NIAID NIH HHS R21 AI144722NIAID NIH HHS U19 AI104317NIAID NIH HHS UM1 AI114271NIEHS NIH HHS P30 ES006694NIH HHS UG3 OD023282NIH HHS UH3 OD023282
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Prenatal Exposure Delayed EffectsAdolescentAdultAir PollutantsAsthmaChildChild, PreschoolEpigenesis, GeneticFemaleHumansInfantInfant, NewbornMaleMaternal ExposureMicrobiotaPregnancyAir Pollutants

Identifiers

PMID33493428
PMCPMC8017579
OpenAlexW3123159881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.