ArticleRheumatology (Oxford, England)2021
Pain and fatigue are longitudinally and bi-directionally associated with more sedentary time and less standing time in rheumatoid arthritis.
Article in Rheumatology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sedentary behaviour interventions in rheumatoid arthritis and osteoarthritis: a systematic scoping review of intervention content, perceived acceptability and efficacy.BMC rheumatology · 2025Pooled it
- Similar negative effects of fatigue on physical activity in persons with rheumatoid arthritis and healthy controls: results of a cross-sectional patient-control study.EULAR rheumatology open · 2026Article
- Facilitators and Barriers to Integrating Sleep Recommendations for Counselling Patients With Arthritis: A Survey of Physiotherapists and Students in Canada.Physiotherapy Canada. Physiotherapie Canada · 2026Article
- Anxiety sensitivity sub-facets and pain intensity and disability among individuals seeking treatment for weight-related behaviors.Journal of behavioral medicine · 2025Article
- Systematic review: digital biomarkers of fatigue in chronic diseases.NPJ digital medicine · 2025Article
- Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases.NPJ digital medicine · 2025Article
- Active and productive ageing in India: evidence from the time use pattern of ageing adults.BMC geriatrics · 2023Article
- Article
- Barriers and facilitators for physical activity in rheumatic and musculoskeletal disease: a European-based survey.Clinical rheumatology · 2023Article
- Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case-control study.Arthritis research & therapy · 2023Article
- Automatic approach-avoidance tendency toward physical activity, sedentary, and neutral stimuli as a function of age, explicit affective attitude, and intention to be active.Peer community journal · 2023Article
- The behavioural epidemiology of sedentary behaviour in inflammatory arthritis: where are we, and where do we need to go?Rheumatology advances in practice · 2023Review
- Article
- The challenges of measuring physical activity and sedentary behaviour in people with rheumatoid arthritis.Rheumatology advances in practice · 2023Review
- Identification and Prediction of Fatigue Trajectories in People With Rheumatoid Arthritis.ACR open rheumatology · 2022Article
- Post-COVID-19 Syndrome and the Potential Benefits of Exercise.International journal of environmental research and public health · 2021Review
- Monitoring and Managing Cardiovascular Risk in Immune Mediated Inflammatory Diseases.Journal of inflammation research · 2021Review
- Fatigue-Related Changes of Daily Function: Most Promising Measures for the Digital Age.Digital biomarkersReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesThe aims of this study were to examine the longitudinal and bi-directional associations of pain and fatigue with sedentary, standing and stepping time in RA.
methodsPeople living with RA undertook identical assessments at baseline (T1, n = 104) and 6-month follow-up (T2, n = 54). Participants completed physical measures (e.g. height, weight, BMI) and routine clinical assessments to characterize RA disease activity (DAS-28). Participants also completed questionnaires to assess physical function (HAQ), pain (McGill Pain Questionnaire) and fatigue (Multidimensional Assessment of Fatigue Scale). Participants' free-living sedentary, standing and stepping time (min/day) were assessed over 7 days using the activPAL3µ™. For the statistical analysis, hierarchical regression analysis was employed to inform the construction of path models, which were subsequently used to examine bi-directional associations of pain and fatigue with sedentary, standing and stepping time. Specifically, where significant associations were observed in longitudinal regression analysis, the bi-directionality of these associations was further investigated via path analysis. For regression analysis, bootstrapping was applied to regression models to account for non-normally distributed data, with significance confirmed using 95% CIs. Where variables were normally distributed, parametric, non-bootstrapped statistics were also examined (significance confirmed via β coefficients, with P < 0.05) to ensure all plausible bi-directional associations were examined in path analysis.
resultsLongitudinal bootstrapped regression analysis indicated that from T1 to T2, change in pain, but not fatigue, was positively associated with change in sedentary time. In addition, change in pain and fatigue were negatively related to change in standing time. Longitudinal non-bootstrapped regression analysis demonstrated a significant positive association between change in fatigue with change in sedentary time. Path analysis supported the hypothesized bi-directionality of associations between change in pain and fatigue with change in sedentary time (pain, β = 0.38; fatigue, β = 0.44) and standing time (pain, β = -0.39; fatigue, β = -0.50).
conclusionFindings suggest pain and fatigue are longitudinally and bi-directionally associated with sedentary and standing time in RA.
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