Evidence map›Paper›PMID 33493033›Full record

ReviewCirculation2021

Research Priorities in Atrial Fibrillation Screening: A Report From a National Heart, Lung, and Blood Institute Virtual Workshop.

Emelia J Benjamin, Alan S Go, Patrice Desvigne-Nickens, Christopher D Anderson, Barbara Casadei, Lin Y Chen, Harry J G M Crijns, Ben Freedman, Mellanie True Hills, Jeff S Healey and 16 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Systematic, randomized atrial fibrillation screening using detailed phenotyping with a risk prediction model combined with patch electrocardiogram in a Swedish population aged 65 years or older: the CONSIDERING-AF trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Consumer-grade wearable devices in arrhythmia diagnostics for clinicians: where we are and where we are going.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Screening and diagnosis of atrial fibrillation using wearable devices.The Korean journal of internal medicine · 2025
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Insertable cardiac monitoring results in higher rates of atrial fibrillation diagnosis and oral anticoagulation prescription after ischaemic stroke.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Emelia J BenjaminCardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (E.J.B.).
Alan S GoDivision of Research, Kaiser Permanente Northern California, Oakland (A.S.G.).
Patrice Desvigne-NickensDivision of Cardiovascular Sciences (P.D.-N., L.S.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Christopher D AndersonDepartment of Neurology, Center for Genomic Medicine, and McCance Center for Brain Health, Massachusetts General Hospital, Boston (C.D.A.).
Barbara CasadeiDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK (B.C.).
Lin Y ChenCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (L.Y.C.).
Harry J G M CrijnsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, the Netherlands (H.J.G.M.C.).
Ben FreedmanHeart Research Institute, Charles Perkins Centre, and Concord Hospital Department of Cardiology, Concord Clinical School, University of Sydney, Australia (B.F.).
Mellanie True HillsStopAfib.org, American Foundation for Women's Health, Decatur, TX (M.T.H.).
Jeff S HealeyPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada (J.S.H.).
Hooman KamelClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY (H.K.).
Dong-Yun KimOffice of Biostatistics Research (D.-Y.K.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Mark S LinkDepartment of Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX (M.S.L.).
Renato D LopesDivision of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (R.D.L., J.P.P., S.M.A.-K.).
Steven A LubitzCardiovascular Research Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, Harvard Medical School, Boston (S.A.L.).
David D McManusDepartment of Medicine, Division of Cardiology, University of Massachusetts Medical School, Worcester (D.D.M.).
Peter A NoseworthyDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (P.A.N.).
Marco V PerezCardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (E.J.B.).
Jonathan P PicciniDivision of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (R.D.L., J.P.P., S.M.A.-K.).
Renate B SchnabelDepartment of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany (R.B.S.).
Daniel E SingerDivision of General Internal Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, (D.E.S.).
Robert G TielemanDepartment of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (I.C.V.G., R.G.T.).
Mintu P TurakhiaCenter for Digital Health (M.P.T.), Stanford University, CA.
Isabelle C Van GelderDepartment of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (I.C.V.G., R.G.T.).
Lawton S CooperDivision of Cardiovascular Sciences (P.D.-N., L.S.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Sana M Al-KhatibDivision of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (R.D.L., J.P.P., S.M.A.-K.).

Funding

The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep DiseasesU54HL143541 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Nathaniel Scott Hafer · 2018 to 2026
$141.0M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Atrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESAR01HL127659 · NHLBI · UNIVERSITY OF WASHINGTON · PI HECKBERT, SUSAN R · 2015 to 2018
$7.4M
Subclinical Atrial Fibrillation and Supraventricular Ectopy in the Jackson Heart StudyR01HL142599 · NHLBI · UNIVERSITY OF WASHINGTON · PI FLOYD, JAMES S · 2018 to 2022
$4.9M
The Atrial Fibrillation - Factor Identification to Risk Modification Study in HDR01DK095024 · NIDDK · STANFORD UNIVERSITY · PI WINKELMAYER, WOLFGANG CHRISTOPH · 2012 to 2023
$4.3M
MRI Detection of CarotId Plaques as a mecHanism for Embolic strokes of undeteRmined source (MRI DECIPHER)R01HL144541 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUPTA, AJAY, KAMEL, HOOMAN · 2019 to 2023
$3.9M
Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling ElderlyR01HL126637 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2016 to 2020
$3.7M
The WHI Strong and Healthy SilenT Atrial fibrillation Recording study (WHISH STAR)R01HL136390 · NHLBI · STANFORD UNIVERSITY · PI PEREZ, MARCO V · 2017 to 2021
$3.6M
Optimizing Atrial Fibrillation Management in CKDR01HL142834 · NHLBI · UNIVERSITY OF WASHINGTON · PI BANSAL, NISHA, GO, ALAN S · 2019 to 2022
$3.4M
Sequencing Annotation and Functional Analysis in Risk of Intracerebral HemorrhageR01NS103924 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2018 to 2022
$3.4M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
CAPSITE: Community Assessment of Pain and Sensitization in the ElderlyR01AG066010 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., EDWARDS, ROBERT R · 2020 to 2025
$3.3M
American Heart Association-American Stroke Association 18SFRN34110082British Heart Foundation CH/12/3/29609British Heart Foundation RG/18/6/33576NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL126637NHLBI NIH HHS R01 HL126911NHLBI NIH HHS R01 HL127659NHLBI NIH HHS R01 HL128595NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL135219NHLBI NIH HHS R01 HL136390NHLBI NIH HHS R01 HL136660NHLBI NIH HHS R01 HL137734NHLBI NIH HHS R01 HL137794NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL141288NHLBI NIH HHS R01 HL141434NHLBI NIH HHS R01 HL142599NHLBI NIH HHS R01 HL142834NHLBI NIH HHS R01 HL144541NHLBI NIH HHS U54 HL143541NIA NIH HHS R01 AG066010NIDDK NIH HHS R01 DK095024NIDDK NIH HHS R01 DK103612NINDS NIH HHS R01 NS097443NINDS NIH HHS R01 NS103924
6 · The paper itself

Abstract

Clinically recognized atrial fibrillation (AF) is associated with higher risk of complications, including ischemic stroke, cognitive decline, heart failure, myocardial infarction, and death. It is increasingly recognized that AF frequently is undetected until complications such as stroke or heart failure occur. Hence, the public and clinicians have an intense interest in detecting AF earlier. However, the most appropriate strategies to detect undiagnosed AF (sometimes referred to as subclinical AF) and the prognostic and therapeutic implications of AF detected by screening are uncertain. Our report summarizes the National Heart, Lung, and Blood Institute's virtual workshop focused on identifying key research priorities related to AF screening. Global experts reviewed major knowledge gaps and identified critical research priorities in the following areas: (1) role of opportunistic screening; (2) AF as a risk factor, risk marker, or both; (3) relationship between AF burden detected with long-term monitoring and outcomes/treatments; (4) designs of potential randomized trials of systematic AF screening with clinically relevant outcomes; and (5) role of AF screening after ischemic stroke. Our report aims to inform and catalyze AF screening research that will advance innovative, resource-efficient, and clinically relevant studies in diverse populations to improve the diagnosis, management, and prognosis of patients with undiagnosed AF.

Indexed as

AgedAtrial FibrillationBiomedical ResearchEducationHumansMass ScreeningNational Heart, Lung, and Blood Institute (U.S.)Treatment OutcomeUnited StatesUser-Computer Interfaceatrial fibrillationdiagnostic screening programsprevention and controlresearchstroke

Identifiers

PMID33493033
PMCPMC8776506

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.