ReviewChemical reviews2021
Hexadehydro-Diels-Alder Reaction: Benzyne Generation via Cycloisomerization of Tethered Triynes.
Review in Chemical reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Bottom-Up Approach for the Synthesis of Contorted Nanographenes by Cp*Co(III)-Catalyzed Annulative-π-Extension-Cyclization Cascade.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Transition Metal-Free Heteroarene Insertion Into C─C Bonds of Benzocyclobutenones.Angewandte Chemie (International ed. in English) · 2026Article
- 1The Journal of organic chemistry · 2026Article
- Sulfonyl-Directed Photoinduced Dehydro-Diels-Alder Reaction of Aryl Maleimides: Enabling Regioselective Naphthalene Synthesis.JACS Au · 2026Article
- Hexadehydro Diels-Alder/Alkynyliodanation Cascade: A Highly Regioselective Entry to Polycyclic Aromatics.Organic letters · 2025Article
- Utilizing the Pentadehydro-Diels-Alder Reaction for Polycyclic Aromatic Compound Synthesis: Diels-Alder-Based Linker Transformation.Molecules (Basel, Switzerland) · 2025Article
- Geometric distortion as an enabling tool for organic synthesis.Nature synthesis · 2025Article
- Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules.Chemical reviews · 2025Review
- A strategy to access unprecedented reactive intermediates featuring carbenes, carbocations, biradicals, and inverted σ-bonds via hypervalent λProceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- An Untethered and Formal Intermolecular Hexadehydro-Diels-Alder Reaction: Alkynylboronates with 2-(1,3-Butadiynyl)pyridines.Journal of the American Chemical Society · 2024Article
- A solution to the anti-Bredt olefin synthesis problem.Science (New York, N.Y.) · 2024Article
- Intermolecular radical oxyalkylation of arynes with alkenes and TEMPO.Chemical science · 2024Article
- Cycloadditions of Benzynes with the Azoxy [RN═NOrganic letters · 2024Article
- Free carbenes from complementarily paired alkynes.Nature chemistry · 2024Article
- Cascade reactions of HDDA-benzynes with tethered cyclohexadienones: strain-driven events originating fromChemical science · 2024Article
- 2:1 Adducts Arising from Reactions between Benzynes and 1,3,4-Oxadiazoles.Organic letters · 2024Article
- Switchable chemoselective aryne reactions between nucleophiles and pericyclic reaction partners using either 3-methoxybenzyne or 3-silylbenzyne.Nature communications · 2024Article
- Room Temperature Diels-Alder Reactions of 4-Vinylimidazoles.Molecules (Basel, Switzerland) · 2024Article
- Cascade Aryne Aminoarylation for Biaryl Phenol Synthesis.Organic letters · 2024Article
- Phosphorane-Promoted C-C Coupling during Aryne Annulations.Angewandte Chemie (International ed. in English) · 2024Article
Corrections and comments
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2 authors.
Funding
Abstract
The hexadehydro-Diels-Alder (HDDA) reaction is the thermal cyclization of an alkyne and a 1,3-diyne to generate a benzyne intermediate. This is then rapidly trapped, in situ, by a variety of species to yield highly functionalized benzenoid products. In contrast to nearly all other methods of aryne generation, no other reagents are required to produce an HDDA benzyne. The versatile and customizable nature of the process has attracted much attention due not only to its synthetic potential but also because of the fundamental mechanistic insights the studies often afford. The authors have attempted to provide here a comprehensive compilation of publications appearing by mid-2020 that describe experimental results of HDDA reactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.