Observational studyASAIO journal (American Society for Artificial Internal Organs : 1992)2021
SARS-CoV-2 Leakage From the Gas Outlet Port During Extracorporeal Membrane Oxygenation for COVID-19.
Observational study in ASAIO journal (American Society for Artificial Internal Organs : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Condensation in a Membrane Oxygenator Analyzed by Bronchoscopy and Ultrasonography.Artificial organs · 2026Article
- Determining Accurate Pore Structures of Polypropylene Membrane for ECMO Using FE-SEM Under Optimized Conditions.Membranes · 2025Article
- Long-term in vivo performance of silicone membrane lungs coated with novel methacryloyloxyethyl phosphorylcholine polymers: A pilot study.Artificial organs · 2025Article
- Characterization of anisotropic pore structure and dense selective layer of capillary membranes for long-term ECMO by cross-sectional ion-milling method.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- 3D porous structure imaging of membranes for medical devices using scanning probe microscopy and electron microscopy: from membrane science points of view.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024Review
- Evolutions of extracorporeal membrane oxygenator (ECMO): perspectives for advanced hollow fiber membrane.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024Review
- A Study of the Phosphorylcholine Polymer Coating of a Polymethylpentene Hollow Fiber Membrane.Polymers · 2023Article
- Article
- Insights into Gradient and Anisotropic Pore Structures of CapioxMembranes · 2022Article
- Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with the coronavirus disease 2019 (COVID-19) sometimes develop refractory respiratory failure and may require venovenous extracorporeal membrane oxygenation (VV-ECMO). It is known that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is sometimes present in the blood of COVID-19 patients. VV-ECMO is often used for several weeks, and plasma leaks can occur, albeit rarely. Hence, in terms of infection control, a concern is that SARS-CoV-2 may leak from the gas outlet port of the oxygenator during ECMO support of critically ill COVID-19 patients. The aim of this study was to clarify whether SARS-CoV-2 leaks from the oxygenator during ECMO support. Five patients with critical COVID-19 pneumonia were placed on VV-ECMO. Silicone-coated polypropylene membrane oxygenators were used in the ECMO circuits for these patients. SARS-CoV-2 ribonucleic acid (RNA) was measured by quantitative reverse transcription polymerase chain reaction in serum and at the gas outlet port of the ECMO circuit at the time of circuit replacement or liberation from ECMO. SARS-CoV-2 RNA was detected in the gas outlet port of the ECMO circuit for three of the five patients. None of the medical staff involved in the care of these five patients has been infected with COVID-19. In conclusion, SARS-CoV-2 could leak to the gas outlet port of the ECMO circuit through silicone-coated polypropylene membranes during ECMO support of critically ill COVID-19 patients.
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