ArticleJournal of thrombosis and haemostasis : JTH2021
Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis.
Article in Journal of thrombosis and haemostasis : JTH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Challenges in PT/INR harmonization across the total testing process.Biochemia medica · 2026Review
- Platelet glycoprotein VI modulates leukocyte characteristics in sepsis-induced systemic inflammatory response in male mice.Physiological reports · 2026Article
- Possible contribution of the STAT3 signaling pathway to disseminated intravascular coagulation (DIC) in mice with cecal ligation and puncture-induced sepsis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Correlation between sub-phenotypes of coagulopathy and prognosis in sepsis patients in ICU using longitudinal group trajectory modeling: a retrospective analysis.European journal of medical research · 2026Article
- Leveraging laboratory biomarkers to predict urosepsis after upper urinary tract stone surgery: an explainable machine learning approach.BMC medical informatics and decision making · 2025Article
- Article
- Inflammation-Associated Coagulation Reactions are Associated with the Prognosis in Critically Ill Very Old Patients (VOPs) with Infection.Journal of inflammation research · 2024Article
- Histone Citrullination Mediates a Protective Role in Endothelium and Modulates Inflammation.Cells · 2022Article
- Hematologic System Dysregulation in Critically Ill Septic Patients with Anemia-A Retrospective Cohort Study.International journal of environmental research and public health · 2022Observational
- Biomarkers Predicting Tissue Pharmacokinetics of Antimicrobials in Sepsis: A Review.Clinical pharmacokinetics · 2022Review
- Pathophysiology of COVID-19: Critical Role of Hemostasis.Frontiers in cellular and infection microbiology · 2022Review
- Sepsis: Evidence-based pathogenesis and treatment.World journal of critical care medicine · 2021Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA prolonged prothrombin time (PT) is a common feature in sepsis indicating consumptive coagulopathy.
objectivesTo determine the association between a prolonged PT and aberrations in other host response mechanisms in sepsis.
methodsPatients admitted to the intensive care unit with sepsis were divided in quartiles according to the highest PT value measured within 24 h after admission. The host response was evaluated by measuring 19 plasma biomarkers reflecting pathways implicated in sepsis pathogenesis and by blood leukocyte gene expression profiling. MEASUREMENTS AND MAIN
resultsOf 1524 admissions for sepsis, 386 (25.3%) involved patients with a normal PT (≤12.7 s); the remaining quartiles entailed 379 (24.9%) patients with a slightly prolonged PT (12.8 ≤ PT ≤ 15.0 s), 383 (25.1%) with an intermediately prolonged PT (15.1 ≤ PT ≤ 17.2 s), and 376 (24.7%) with an extremely prolonged PT (≥17.3 s). While patients with an extremely prolonged PT showed an increased crude mortality up to 1 year after admission, none of the prolonged PT groups was independently associated with 30-day adjusted mortality. Comparison of the host response between patients with a normal PT or an extremely prolonged PT matched for baseline characteristics including severity of disease showed that an extremely prolonged PT was associated with impaired anticoagulant mechanisms, a more disturbed endothelial barrier integrity and increased systemic inflammation, and blood leukocyte transcriptomes indicating more prominent metabolic reprogramming and protein catabolism.
conclusionA prolonged PT is associated with stronger anomalies in pathways implicated in the pathogenesis of sepsis, suggesting that activation of coagulation impacts other host response mechanisms.
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