Evidence map›Paper›PMID 33492705›Full record

ArticleAngewandte Chemie (International ed. in English)2021

GlycoBODIPYs: Sugars Serving as a Natural Stock for Water-soluble Fluorescent Probes of Complex Chiral Morphology.

Lukas J Patalag, Somayeh Ahadi, Olesia Lashchuk, Peter G Jones, Simon Ebbinghaus, Daniel B Werz

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  7. The Journal of organic chemistry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lukas J PatalagTU Braunschweig, Institute of Organic Chemistry, Hagenring 30, 38106, Braunschweig, Germany.
Somayeh AhadiTU Braunschweig, Institute of Organic Chemistry, Hagenring 30, 38106, Braunschweig, Germany.
Olesia LashchukTU Braunschweig, Institute of Physical and Theoretical Chemistry, and Braunschweig Integrated Centre of Systems Biology, Rebenring 56, 38106, Braunschweig, Germany.
Peter G JonesTU Braunschweig, Institute of Inorganic and Analytical Chemistry, Hagenring 30, 38106, Braunschweig, Germany.
Simon EbbinghausTU Braunschweig, Institute of Physical and Theoretical Chemistry, and Braunschweig Integrated Centre of Systems Biology, Rebenring 56, 38106, Braunschweig, Germany.ORCID 0000-0001-9309-1279
Daniel B WerzTU Braunschweig, Institute of Organic Chemistry, Hagenring 30, 38106, Braunschweig, Germany.ORCID 0000-0002-3973-2212

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A range of unprocessed, reducing sugar substrates (mono-, di-, and trisaccharides) is shown to take part in a straightforward four-step synthetic route to water-soluble, uncharged BODIPY derivatives with unimpaired chiral integrity and high fluorescence efficiency. A wide compatibility with several postfunctionalizations is demonstrated, thus suggesting a universal utility of the multifunctional glycoconjugates, which we call GlycoBODIPYs. Knoevenagel condensations are able to promote a red-shift in the spectra, thereby furnishing strongly fluorescent red and far-red glycoconjugates of high hydrophilicity. The synthetic outcome was studied by X-ray crystallography and by comprehensive photophysical investigations in several solvent systems. Furthermore, cell experiments illustrate efficient cell uptake and demonstrate differential cell targeting as a function of the integrated chiral information.

Indexed as

Boron CompoundsFluorescent DyesGlycosylationHeLa CellsHumansMolecular StructureSolubilitySugarsWater4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsFluorescent DyesSugarsWatercarbohydratescell imagingdyesfluorophoreswater solubility

Identifiers

PMID33492705
PMCPMC8048574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.