Evidence map›Paper›PMID 33492681›Full record

ArticleThe Journal of physiology2021

Nicotinamide riboside supplementation does not alter whole-body or skeletal muscle metabolic responses to a single bout of endurance exercise.

Ben Stocks, Stephen P Ashcroft, Sophie Joanisse, Linda C Dansereau, Yen Chin Koay, Yasir S Elhassan, Gareth G Lavery, Lake-Ee Quek, John F O'Sullivan, Ashleigh M Philp and 2 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. NADNature metabolism · 2025
    Review
  8. Protein Acetylation and NAD+ Homeostasis in Aging Muscle.Advances in experimental medicine and biology · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Review
  14. Review
  15. Nicotinamide Riboside, a Promising Vitamin BMolecules (Basel, Switzerland) · 2023
    Review
  16. Review
  17. NADSports medicine (Auckland, N.Z.) · 2022
    Review
  18. Article
  19. Balancing NADCellular and molecular life sciences : CMLS · 2022
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ben StocksSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Stephen P AshcroftSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Sophie JoanisseSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Linda C DansereauMitochondrial Metabolism and Ageing Laboratory, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.ORCID 0000-0002-0522-8309
Yen Chin KoayCharles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia.
Yasir S ElhassanInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.
Gareth G LaveryInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.
Lake-Ee QuekCharles Perkins Centre, School of Mathematics and Statistics, University of Sydney, Sydney, NSW, Australia.
John F O'SullivanCharles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia.
Ashleigh M PhilpMitochondrial Metabolism and Ageing Laboratory, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.
Gareth A WallisSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0002-1400-0859
Andrew PhilpSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0003-3860-4136
University of Birmingham · GBGarvan Institute of Medical Research · AUThe University of Sydney · AU

Funding

Biotechnology and Biological Sciences Research Council BB/J014532/1Biotechnology and Biological Sciences Research Council BB/L023547/1
6 · The paper itself

Abstract

key pointsAcute nicotinamide riboside (NR) supplementation does not alter substrate metabolism at rest, during or in recovery from endurance exercise. NR does not alter NAD ABSTRACT: Oral supplementation of the NAD

Indexed as

Muscle, SkeletalNiacinamideDietary SupplementsExerciseHumansMaleNADPyridinium CompoundsNADNiacinamidenicotinamide-beta-ribosidePyridinium CompoundsexercisemetabolismNAD+skeletal muscle

Identifiers

PMID33492681
OpenAlexW3123614069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.