Evidence map›Paper›PMID 33492651›Full record

ArticleLa Radiologia medica2021

Shear wave elastography and transient elastography in HCV patients after direct-acting antivirals.

Giulio Argalia, Giuseppe Tarantino, Claudio Ventura, Daniele Campioni, Corrado Tagliati, Paola Guardati, Alba Kostandini, Marco Marzioni, Gian Marco Giuseppetti, Andrea Giovagnoni

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Article in La Radiologia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Giulio ArgaliaDepartement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy. giulio.argalia@gmail.com.ORCID http://orcid.org/0000-0001-5422-5625
Giuseppe TarantinoClinic of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ospedali Riuniti - University Hospital, Via Tronto 10, 60126, Ancona, Italy.
Claudio VenturaDepartement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy.
Daniele CampioniDepartement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy.
Corrado TagliatiDepartement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy.
Paola GuardatiClinic of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ospedali Riuniti - University Hospital, Via Tronto 10, 60126, Ancona, Italy.
Alba KostandiniClinic of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ospedali Riuniti - University Hospital, Via Tronto 10, 60126, Ancona, Italy.
Marco MarzioniClinic of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ospedali Riuniti - University Hospital, Via Tronto 10, 60126, Ancona, Italy.
Gian Marco GiuseppettiDepartement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy.
Andrea GiovagnoniDepartement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy.
Ospedali Riuniti di Ancona · ITMarche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the ultrasound (US) and pulse shear wave elastography (pSWE, Elast PQ

methodsOur prospective study from June 2016 to December 2017 included 22 consecutively enrolled HCV-positive patients (59.7 ± 12.3 years, 11 male) which were subjected to antiviral therapy. All patients underwent B-mode ultrasound, color-Doppler, pSWE and TE five times: before therapy (T0), at the end of therapy (post-Tx), and at 12, 24, 48 weeks post-therapy. The liver stiffness (LS) values obtained with pSWE and TE and the data coming from US assessment and clinical evaluation were compared.

resultsWe obtained a statistically significant reduction of LS values (kPa) measured by pSWE, between T0 (14.3 ± 9.3), post-Tx (11.8 ± 10.5), 12 weeks (7.5 ± 3.3), 24 weeks (8 ± 3.8) and 48 weeks (8.5 ± 4.6) (p = 0.02). The reduction of kPa measured by TE was not significant between T0 (14.7 ± 9.3), post-Tx (12 ± 9.5), 12 weeks (11.6 ± 7.7), 24 weeks (10.3 ± 6) and 48 weeks (10.8 ± 7.5) (p > 0.05). Multivariate baseline analysis showed significant independent association among measurement of TE stiffness with cirrhosis, type of vein hepatic flow and showed significant independent association between delta-pSWE measurement (difference between stiffness measurements at the baseline and 12 months after treatment) with staging of fibrosis (p = 0.006) and sustained virologic response after 12 weeks of treatment (SVR12, p = 0.017).

conclusionThe pSWE method has shown better ability than TE to identify a reduction in LS. Therefore, pSWE allow to evaluate stiffness reduction in HCV patient during DAA treatment follow-up, which is related to SVR12.

Indexed as

Antiviral AgentsElasticity Imaging TechniquesFemaleFollow-Up StudiesHepatitis C, ChronicHumansLiverMaleMiddle AgedProspective StudiesReproducibility of ResultsAntiviral AgentsDirect antiviral acting drugsLiver stiffnessPulse shear wave elastographySustained virological responseTransient elastosonography

Identifiers

PMID33492651
OpenAlexW3122329813

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.