Evidence map›Paper›PMID 33492599›Full record

ArticleCellular and molecular neurobiology2022

Glutamatergic System is Affected in Brain from an Hyperthermia-Induced Seizures Rat Model.

M Crespo, D A León-Navarro, M Martín

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. NaInternational journal of molecular sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

M CrespoDepartment of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Universidad de Castilla-La Mancha, Regional Centre of Biomedical Research (CRIB), Avenida Camilo José Cela, 10, 13071, Ciudad Real, Spain.ORCID http://orcid.org/0000-0001-5716-6333
D A León-NavarroDepartment of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Universidad de Castilla-La Mancha, Regional Centre of Biomedical Research (CRIB), Avenida Camilo José Cela, 10, 13071, Ciudad Real, Spain. Davidagustin.leon@uclm.es.ORCID http://orcid.org/0000-0002-5539-9237
M MartínDepartment of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Universidad de Castilla-La Mancha, Regional Centre of Biomedical Research (CRIB), Avenida Camilo José Cela, 10, 13071, Ciudad Real, Spain.ORCID http://orcid.org/0000-0002-6843-3449
University of Castilla-La Mancha · ES

Funding

Agencia Estatal de Investigación PID2019-109206GB-I00Junta de Comunidades de Castilla-La Mancha SBPLY/19/180501/000251Universidad de Castilla-La Mancha 2020-GRIN-29108
6 · The paper itself

Abstract

One of the most frequent neurological disorders in children is febrile seizures (FS), a risk for epilepsy in adults. Glutamate is the main excitatory neurotransmitter in CNS acting through ionotropic and metabotropic receptors. Excess of glutamate in the extracellular space elicits excitotoxicity and has been associated with neurological disorders, such as epilepsy. The removal of extracellular glutamate by excitatory amino acid transporters (EATT) plays an important neuroprotective role. GLT-1 is the main EAAT present in the cortex brain. On the other hand, an increase in metabotropic glutamate receptors 5 (mGlu

Indexed as

EpilepsyHyperthermia, InducedSeizures, FebrileAnimalsBrainGlutamic AcidRatsGlutamic AcidEpilepsyGlutamateHyperthermia seizureMetabotropic glutamate receptor

Identifiers

PMID33492599
PMCPMC11421758
OpenAlexW3122231542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.