ArticleMolecular biology reports2021
Rutin improves glutamate uptake and inhibits glutamate excitotoxicity in rat brain slices.
Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Flavonoid Rutin Reduces Intestinal Inflammation in an Experimental Model of Parkinson's Disease.Neurotoxicity research · 2026Article
- Molecular mechanisms of neuroprotective effect of rutin.Frontiers in pharmacology · 2025Review
- The Neuroprotective Effect of Rooibos Herbal Tea Against Alzheimer's Disease: A Review.Molecular nutrition & food research · 2025Review
- Unraveling neuroprotection with Kv1.3 potassium channel blockade by a scorpion venom peptide.Scientific reports · 2024Article
- The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment.Neurochemical research · 2024Review
- Effect of the Flavonoid Rutin on the Modulation of the Myenteric Plexuses in an Experimental Model of Parkinson's Disease.International journal of molecular sciences · 2024Article
- Therapeutic potential of rutin in premenstrual depression: evidence fromFrontiers in pharmacology · 2024Article
- Protective Effects of Flavonoid Rutin Against Aminochrome Neurotoxicity.Neurotoxicity research · 2023Article
- Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia.BMC complementary medicine and therapies · 2023Article
- Rutin Improves Anxiety and Reserpine-Induced Depression in Rats.Molecules (Basel, Switzerland) · 2022Article
- Influences of Microwave-Assisted Extraction Parameters on Antioxidant Activity of the Extract fromFoods (Basel, Switzerland) · 2021Article
- Potential of rutin fromJournal of advanced pharmaceutical technology & researchArticle
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
Rutin is an important flavonoid consumed in the daily diet. It is also known as vitamin P and has been extensively investigated due to its pharmacological properties. On the other hand, neuronal death induced by glutamate excitotoxicity is present in several diseases including neurodegenerative diseases. The neuroprotective properties of rutin have been under investigation, although its mechanism of action is still poorly understood. We hypothesized that the mechanisms of neuroprotection of rutin are associated with the increase in glutamate metabolism in astrocytes. This study aimed to evaluate the protective effects of rutin with a focus on the modulation of glutamate detoxification. We used brain organotypic cultures from post-natal Wistar rats (P7-P9) treated with rutin to evaluate neural cell protection and levels of proteins involved in the glutamate metabolism. Moreover, we used cerebral cortex slices from adult Wistar rats to evaluate glutamate uptake. We showed that rutin inhibited the cell death and loss of glutamine synthetase (GS) induced by glutamate that was associated with an increase in glutamate-aspartate transporter (GLAST) in brain organotypic cultures from post-natal Wistar rats. Additionally, it was observed that rutin increased the glutamate uptake in cerebral cortex slices from adult Wistar rats. We conclude that rutin is a neuroprotective agent that prevents glutamate excitotoxicity and thereof suggest that this effect involves the regulation of astrocytic metabolism.
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