ArticleBrain structure & function2021
Sim1-expressing cells illuminate the origin and course of migration of the nucleus of the lateral olfactory tract in the mouse amygdala.
Article in Brain structure & function, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Divergent structural trajectories for pallial regionalization within reptiles reveal conserved evolutionary blueprints.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Transcriptomics reveals pallial and subpallial subdivisions of the mouse medial amygdala.Brain structure & function · 2026Article
- Cortical Type: The Basis for a Modern Neurodevelopmental Synthesis (Ontogeny, Phylogeny, Synaptic Connectivity) of the Human Cerebral Cortex.The Journal of comparative neurology · 2026Review
- Transcriptomic Analysis Corroborates the New Radial Model of the Mouse Pallial Amygdala.Biomolecules · 2025Article
- Development and function of the medial amygdala.Trends in neurosciences · 2025Review
- Synaptic Connectivity and Electrophysiological Properties of the Nucleus of the Lateral Olfactory Tract.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuronal types in the mouse amygdala and their transcriptional response to fear conditioning.Nature neuroscience · 2023Article
- Nucleus of the lateral olfactory tract: A hub linking the water homeostasis-associated supraoptic nucleus-arginine vasopressin circuit and neocortical regions to promote social behavior under osmotic challenge.Journal of neuroendocrinology · 2023Article
- Dorsoventral Arrangement of Lateral Hypothalamus Populations in the Mouse Hypothalamus: a Prosomeric Genoarchitectonic Analysis.Molecular neurobiology · 2023Article
- Molecular Diversity of Neuron Types in the Salamander Amygdala and Implications for Amygdalar Evolution.Brain, behavior and evolution · 2023Article
- Developmental genoarchitectonics as a key tool to interpret the mature anatomy of the chondrichthyan hypothalamus according to the prosomeric model.Frontiers in neuroanatomy · 2022Article
- Developmental-Based Classification of Enkephalin and Somatostatin Containing Neurons of the Chicken Central Extended Amygdala.Frontiers in physiology · 2022Article
- Distinct Subdivisions in the Transition Between Telencephalon and Hypothalamus Produce Otp and Sim1 Cells for the Extended Amygdala in Sauropsids.Frontiers in neuroanatomy · 2022Article
- Prosomeric Hypothalamic Distribution of Tyrosine Hydroxylase Positive Cells in Adolescent Rats.Frontiers in neuroanatomy · 2022Article
- Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression.Brain structure & function · 2021Article
- Novel Perspectives on the Development of the Amygdala in Rodents.Frontiers in neuroanatomy · 2021Review
- Recollections on the Origins and Development of the Prosomeric Model.Frontiers in neuroanatomy · 2021Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
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Abstract
We focus this report on the nucleus of the lateral olfactory tract (NLOT), a superficial amygdalar nucleus receiving olfactory input. Mixed with its Tbr1-expressing layer 2 pyramidal cell population (NLOT2), there are Sim1-expressing cells whose embryonic origin and mode of arrival remain unclear. We examined this population with Sim1-ISH and a Sim1-tauLacZ mouse line. An alar hypothalamic origin is apparent at the paraventricular area, which expresses Sim1 precociously. This progenitor area shows at E10.5 a Sim1-expressing dorsal prolongation that crosses the telencephalic stalk and follows the terminal sulcus, reaching the caudomedial end of the pallial amygdala. We conceive this Sim1-expressing hypothalamo-amygdalar corridor (HyA) as an evaginated part of the hypothalamic paraventricular area, which participates in the production of Sim1-expressing cells. From E13.5 onwards, Sim1-expressing cells migrated via the HyA penetrate the posterior pallial amygdalar radial unit and associate therein to the incipient Tbr1-expressing migration stream which swings medially past the amygdalar anterior basolateral nucleus (E15.5), crosses the pallio-subpallial boundary (E16.5), and forms the NLOT2 within the anterior amygdala by E17.5. We conclude that the Tbr1-expressing NLOT2 cells arise strictly within the posterior pallial amygdalar unit, involving a variety of required gene functions we discuss. Our results are consistent with the experimental data on NLOT2 origin reported by Remedios et al. (Nat Neurosci 10:1141-1150, 2007), but we disagree on their implication in this process of the dorsal pallium, observed to be distant from the amygdala.
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