ArticleJournal of the National Cancer Institute2021
Trends in the Incidence of Young-Onset Colorectal Cancer With a Focus on Years Approaching Screening Age: A Population-Based Longitudinal Study.
Article in Journal of the National Cancer Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Colorectal cancer treatment assisted by robotic platforms - a systematic review.Journal of robotic surgery · 2026Pooled it
- Early-onset colorectal cancer is associated with metabolic disorders: a systematic review and meta-analysis.European journal of epidemiology · 2026Pooled it
- The efficacy and safety of chemoimmunotherapy in patients with MSI-L/MSS/pMMR status metastatic colorectal cancer: a systematic review and meta-analysis of randomized controlled trials.Frontiers in oncology · 2025Pooled it
- Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis.Current oncology (Toronto, Ont.) · 2022Pooled it
- Direct medical costs of young-onset colorectal cancer: a worldwide systematic review.BMC health services research · 2022Pooled it
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- Clinical characteristics and outcomes in patients with early-onset locally advanced rectal cancer.Therapeutic advances in medical oncology · 2026Article
- Colorectal Cancer in Mississippi: How to Change the Tide of Bad News to a Success Story?Cureus · 2025Review
- Factors Associated with Positive Fecal Immunochemical Test Results for Colorectal Cancer Screening among At-Risk Populations in Southern Thailand: A Cross-Sectional Analytic Study.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Colorectal cancer early screening: Dilemmas and solutions.World journal of gastroenterology · 2025Article
- Colorectal Cancer: Pathogenesis and Targeted Therapy.MedComm · 2025Review
- Digestive cancers: mechanisms, therapeutics and management.Signal transduction and targeted therapy · 2025Review
- Prediction of KRAS gene mutations in colorectal cancer using a CT-based radiomic model.Frontiers in medicine · 2025Article
- Risk Prediction of Myelosuppression Following First-line Chemotherapy in Colorectal Cancer.Journal of Cancer · 2025Article
- Mental healthcare utilisation among individuals with colorectal cancer: population-based cohort studies.BMJ oncology · 2025Article
- Article
- Patterns of Prescription Medication Use Before Diagnosis of Early Age-Onset Colorectal Cancer: Population-Based Descriptive Study.JMIR cancer · 2024Article
- The Usefulness of Vitamin K-Dependent Proteins in the Diagnosis of Colorectal Carcinoma.International journal of molecular sciences · 2024Article
- Review
- Efficient organized colorectal cancer screening in Shenzhen: a microsimulation modelling study.BMC public health · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundWith recent evidence for the increasing risk of young-onset colorectal cancer (yCRC), we had the objective to evaluate the incidence of yCRC in 1-year age increments, particularly focusing around the screening age of 50 years.
methodsWe conducted a longitudinal study using linked administrative health databases in British Columbia, Canada, including a provincial cancer registry, inpatient and outpatient visits, and vital statistics from January 1, 1986, to December 31, 2016. We calculated incidence rates per 100 000 at every age from 20 to 60 years and estimated annual percent change in incidence (APCi) of yCRC using joinpoint regression analysis.
resultsWe identified 3614 individuals with yCRC (49.9% women). The incidence of CRC steadily increased from 20 to 60 years, with a marked increase from 49 to 50 years (incidence rate ratio = 1.19, 95% confidence interval [CI] = 1.04 to 1.34). Furthermore, there was a trend of increased incidence of yCRC among women (APCi = 0.79%, 95% CI = 0.22% to 1.36%) and men (APCi = 2.17%, 95% CI = 1.59% to 2.76%). Analyses stratified by age yielded APCis of 2.49% (95% CI = 1.36% to 3.63%) and 0.12% (95% CI = -0.54% to 0.79%) for women aged 30-39 years and 40-49 years, respectively, and 2.97% (95% CI = 1.65% to 4.31%) and 1.86% (95% CI = 1.19% to 2.53%) for men.
conclusionsOur findings indicate a steady increase over 1-year age increments in the risk of yCRC during the years approaching and beyond screening age. These findings highlight the need to raise awareness as well as continue discussions regarding considerations of lowering the screening age.
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