Evidence map›Paper›PMID 33492295›Full record

SynthesisJournal of Alzheimer's disease : JAD2021

Mortality Risk Models for Persons with Dementia: A Systematic Review.

Eric E Smith, Zahinoor Ismail

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Six-Month Prognostic Tool for Community-Dwelling People With Dementia.Journal of the American Geriatrics Society · 2026
    Article
  4. Article
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  6. Impact of dementia-landscaped therapy garden on psychological well-being- A pilot study.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Transitions Between Mild Cognitive Impairment, Dementia, and Mortality: The Importance of Olfaction.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eric E SmithDepartment of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Zahinoor IsmailDepartment of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPersons with dementia have higher mortality than the general population. Objective, standardized predictions of mortality risk in persons with dementia could help with planning resources for care close to the end of life.

objectiveTo systematically review prediction models for risk of death in persons with dementia.

methodsThe Medline and PsycInfo databases were searched on November 29, 2020, for prediction models estimating the risk of death in persons with dementia. Study quality was assessed using the Prediction model Risk Of Bias ASsessment Tool.

resultsThe literature search identified 2,828 studies, of which 18 were included. These studies described 16 different prediction models with c statistics mostly ranging from 0.67 to 0.79. Five models were externally validated, of which four were applicable. There were two models that were both applicable and had reasonably low risk of bias. One model predicted risk of death at six months in persons with advanced dementia residing in a nursing home. The other predicted risk of death at three years in persons seen in primary care practice or a dementia specialty clinic, derived from a nationwide registry in Sweden but not externally validated.

conclusionValid, applicable models with low risk of bias were found in two settings: advanced dementia in a nursing home and outpatient practices. The outpatient model requires external validation. Better models are needed for persons with mild to moderate dementia in nursing homes, a common demographic. These models may be useful for educating persons living with dementia and care partners and directing resources for end of life care.Registration:The study protocol is registered on PROSPERO as RD4202018076.

Indexed as

AgedAged, 80 and overDementiaFemaleHumansMaleMiddle AgedModels, StatisticalNursing HomesOutpatientsPredictive Value of TestsRisk AssessmentDementiamortalityprediction

Identifiers

PMID33492295
PMCPMC8075391

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.