Evidence map›Paper›PMID 33492138›Full record

ArticleACS synthetic biology2021

Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications.

Robert J Lovelett, Evan M Zhao, Makoto A Lalwani, Jared E Toettcher, Ioannis G Kevrekidis, José L Avalos

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Robert J LovelettDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0003-1428-0931
Evan M ZhaoDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.
Makoto A LalwaniDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.
Jared E ToettcherDepartment of Molecular Biology, Princeton, New Jersey 08544, United States.ORCID 0000-0002-1546-4030
Ioannis G KevrekidisDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0003-2220-3522
José L AvalosDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-7209-4208
Princeton University · USJohns Hopkins University · US

Funding

Harnessing optogenetics to diagnose and therapeutically rewire cancer cell signalingDP2EB024247 · NIBIB · PRINCETON UNIVERSITY · PI TOETTCHER, JARED E · 2016 to 2016
$2.4M
NIBIB NIH HHS DP2 EB024247
6 · The paper itself

Abstract

Dynamic control of engineered microbes using light via optogenetics has been demonstrated as an effective strategy for improving the yield of biofuels, chemicals, and other products. An advantage of using light to manipulate microbial metabolism is the relative simplicity of interfacing biological and computer systems, thereby enabling

Indexed as

Models, TheoreticalAlgorithmsBiofuelsFermentationGene ExpressionGene Expression Regulation, FungalKineticsLightMetabolic EngineeringMetabolic Networks and PathwaysOptogeneticsSaccharomyces cerevisiaeBiofuels

Identifiers

PMID33492138
PMCPMC10410538
OpenAlexW3122133550

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.