Evidence map›Paper›PMID 33491508›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Hongbo Liu, Fei Ye, Qi Sun, Hao Liang, Chunmei Li, Siyang Li, Roujian Lu, Baoying Huang, Wenjie Tan, Luhua Lai

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 2 pooled it
43.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 2 syntheses or guidelines pooled it, 308 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Exploring novel isatin derivatives as SARS-CoV-2 3CLJournal of enzyme inhibition and medicinal chemistry · 2026
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  6. Review
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  8. Article
  9. Article
  10. Review
  11. Article
  12. Prediction of baicalin concentration within scutellaria based on terahertz spectroscopy by analyzing aligned principal component.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
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  13. Article
  14. Review
  15. Impact of Glucose, Inflammation and Phytochemicals onAntioxidants (Basel, Switzerland) · 2025
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Hongbo LiuBNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Fei YeNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Qi SunBNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Hao LiangBNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Chunmei LiCenter for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Siyang LiCenter for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Roujian LuNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Baoying HuangNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Wenjie TanNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Luhua LaiBNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Chinese Center For Disease Control and Prevention · CNPeking University · CNCenter for Life Sciences · CNBeijing National Laboratory for Molecular Sciences · CNNational Institute for Viral Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 has become a global pandemic and there is an urgent call for developing drugs against the virus (SARS-CoV-2). The 3C-like protease (3CL

Indexed as

COVID-19 Drug TreatmentAnimalsAntiviral AgentsChlorocebus aethiopsCoronavirus 3C ProteasesCOVID-19Drug DiscoveryEnzyme InhibitorsFlavanonesHumansIn Vitro TechniquesModels, MolecularPlant ExtractsProtease InhibitorsSARS-CoV-2Scutellaria baicalensis3C-like proteinase, SARS-CoV-2Antiviral AgentsbaicaleinCoronavirus 3C ProteasesEnzyme InhibitorsFlavanonesPlant ExtractsProtease InhibitorsScutellaria baicalensis extract3C-like proteasebaicaleinCOVID-19SARS-CoV-2Scutellaria baicalensis

Identifiers

PMID33491508
PMCPMC7850424
OpenAlexW3125201916

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.