Evidence map›Paper›PMID 33491503›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from

Amanda Fernandes de Medeiros, Beatriz Blenda Pinheiro de Souza, Lucas Pinheiro Coutinho, Aline Melro Murad, Paula Ivani Medeiros Dos Santos, Norberto de Kássio Vieira Monteiro, Elizeu Antunes Dos Santos, Bruna Leal Lima Maciel, Ana Heloneida de Araújo Morais

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review.Journal of enzyme inhibition and medicinal chemistry · 2022
    Pooled it
  2. Insulin Resistance, Anti-inflammatory, and AntioxidantBiotechnology reports (Amsterdam, Netherlands) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. ProspectingJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amanda Fernandes de MedeirosPostgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.ORCID https://orcid.org/0000-0002-1354-0116
Beatriz Blenda Pinheiro de SouzaPostgraduate Biological Molecular, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.ORCID https://orcid.org/0000-0002-6793-6386
Lucas Pinheiro CoutinhoChemistry Course, Science Center, Federal University of Ceará, Fortaleza, Brazil.ORCID https://orcid.org/0000-0001-9591-5593
Aline Melro MuradLaboratory of Mass Spectometry-LEM, Embrapa Genetic Resources and Biotechnology, Brasília, Brazil.ORCID https://orcid.org/0000-0003-3222-4001
Paula Ivani Medeiros Dos SantosFederal Institute of Education, Science and Technology of Rio Grande do Norte, Brazil.ORCID https://orcid.org/0000-0003-2955-8174
Norberto de Kássio Vieira MonteiroAnalytical Chemistry and physical Chemistry Department, Science Center, Federal University of Ceará, Fortaleza, Brazil.ORCID https://orcid.org/0000-0002-5847-5733
Elizeu Antunes Dos SantosPostgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.ORCID https://orcid.org/0000-0003-4372-2161
Bruna Leal Lima MacielPostgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.ORCID https://orcid.org/0000-0002-0724-1961
Ana Heloneida de Araújo MoraisPostgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.ORCID https://orcid.org/0000-0002-6460-911X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trypsin inhibitors from tamarind seed have been studied

Indexed as

Molecular Dynamics SimulationDose-Response Relationship, DrugMolecular StructurePlant ExtractsSeedsStructure-Activity RelationshipTamarindusTrypsinTrypsin InhibitorsPlant ExtractsTrypsinTrypsin Inhibitorsantitrypticcomputational methodshomology modellingprotein-protein interactionTamarind

Identifiers

PMID33491503
PMCPMC7875565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.