Trial reportObesity (Silver Spring, Md.)2021
Effect of Aerobic Exercise Intensity on Energy Expenditure and Weight Loss in Severe Obesity-A Randomized Controlled Trial.
Trial report in Obesity (Silver Spring, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07645859 (Comparison of High-Intensity Interval Training With Moderate-Intensity Connuous Training In Chronic Non-Specific Low Back Pain Patients), which is not on this map. Cited by 34 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of High-Intensity Interval Training With Moderate-Intensity Connuous Training In Chronic Non-Specific Low Back Pain Patients: Randomized Clinical Trial
Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Quantitative assessment of efficacy and evaluation of feasibility of exercise training protocols in adult and pediatric primary mitochondrial disease.BMC medicine · 2026Pooled it
- Pooled it
- Effect of High-Intensity Interval Training vs. Moderate-Intensity Continuous Training on Fat Loss and Cardiorespiratory Fitness in the Young and Middle-Aged a Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Effect of High-Intensity Interval Training Combined with Fasting in the Treatment of Overweight and Obese Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Effect of exercise training before and after bariatric surgery: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Combined high-intensity interval and resistance training improves cardiorespiratory fitness more than high-intensity interval training in young women with overweight/obesity: a randomized controlled trial.Frontiers in endocrinology · 2024Trial
- Dual endothelin receptor antagonism increases resting energy expenditure in people with increased adiposity.American journal of physiology. Endocrinology and metabolism · 2022Trial
- Effect of aerobic exercise intensity on health-related quality of life in severe obesity: a randomized controlled trial.Health and quality of life outcomes · 2022Trial
- Effects of Aerobic Exercise on Heart Rate Variability and C-Reactive Protein in Middle-Aged Adults With Normal Weight and Overweight/Obesity: A Pilot Study.Research in nursing & health · 2026Article
- Apigenin Combined with Aerobic Exercise Is Associated with Attenuated Renal Oxidative Stress and AMPK/SIRT1/PGC-1α Pathway Activation in NAFLD Mice.Current issues in molecular biology · 2026Article
- Effects of Sleeve Gastrectomy and Subsequent Whole-Body Vibration Training on Resting Metabolic Rate and Body Composition: A Pilot Randomized Controlled Trial.Obesity surgery · 2026Article
- Pathogenic analysis of post-transplantation obesity: A comprehensive systematic review.World journal of transplantation · 2026Article
- Machine Learning for Estimating Cardiorespiratory Fitness in Patients With Obesity: Protocol for a Retrospective and Prospective Multicenter Cohort Study.JMIR research protocols · 2026Article
- Exercise Guidelines for Enhancing Mobility and Stability in Individuals with Severe Obesity.Journal of obesity & metabolic syndrome · 2026Review
- Physical exercise as a modulator of the sleep-obesity interaction: metabolic, neuroendocrine and circadian mechanisms.Frontiers in sleep · 2026Review
- High-Intensity Interval Training Attenuates Inflammation in Cardiorenal Syndrome Induced by Renal Ischemia-Reperfusion Injury in Rats.Life (Basel, Switzerland) · 2025Article
- Expert consensus statement for basic research of animal exercise intervention studies in chronic disease prevention and treatment: A joint position paper of the Exercise Science branch of the Biophysical Society of China and the Metabolism and Genetics branch of the Genetics Society of China.Journal of sport and health science · 2025Article
- Diurnal timing and volume of physical activity in relation to metabolic syndrome in US adults: a population-based cohort study.International journal of obesity (2005) · 2025Article
- Association of Maternal Sociodemographic, Anthropometric, and Lifestyle Factors with Childhood Anthropometric Measures and Anxiety Symptoms: A Nationally Representative Cross-Sectional Study of Preschool-Aged Children in Greece.Diseases (Basel, Switzerland) · 2025Article
- Effects of six traditional Chinese mind-body exercises on obesity and cardiovascular risk factors in middle-aged and elderly hypertensive patients: a network Meta-Analysis of 49 RCTs.BMC cardiovascular disorders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to compare the effects of two aerobic exercise programs of different intensities on energy expenditure.
methodsThis was a single-center randomized controlled trial of patients with severe obesity allocated to a 24-week moderate-intensity continuous training (MICT) program or a combined MICT with high-intensity interval training (HIIT/MICT) program. The primary outcome was energy expenditure during exercise (EEDE). Secondary outcomes included resting metabolic rate, cardiorespiratory fitness, and body composition.
resultsA total of 82 (56% females) patients were screened, and 71 (55% females) patients were allocated to HIIT/MICT (n = 37) or MICT (n = 34). Per-protocol analysis showed that EEDE increased by 10% (95% CI: 3%-17%) in the HIIT/MICT group (n = 16) and 7.5% (95% CI: 4%-10%) in the MICT group (n = 24), with no differences between groups. In the 8- to 16- week per-protocol analysis, the HIIT/MICT group had a significantly larger increase in EEDE compared with the MICT group. Resting metabolic rate remained unchanged in both groups. HIIT/MICT and MICT were associated with significant weight loss of 5 kg and 2 kg, respectively.
conclusionsPatients completing a 24-week combined HIIT/MICT program did not achieve a higher EEDE compared with those who completed a 24-week MICT program. The HIIT/MICT group experienced, on average, a 3-kg-larger weight loss than the MICT group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.