Evidence map›Paper›PMID 33491310›Full record

ArticleObesity (Silver Spring, Md.)2021

A Genome-Wide Association Study of Childhood Body Fatness.

Erica T Warner, Lai Jiang, David Nana Adjei, Constance Turman, William Gordon, Lu Wang, Rulla Tamimi, Peter Kraft, Sara Lindström

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Erica T WarnerClinical Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-2671-0313
Lai JiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
David Nana AdjeiDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Constance TurmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
William GordonDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Lu WangDepartment of Environmental & Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Rulla TamimiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Sara LindströmDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Harvard University · USUniversity of Washington · USBrigham and Women's Hospital · US

Funding

Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Premonopausal Hormone Levels and Risk of Breast CancerR01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HANKINSON, SUSAN E · 2002 to 2011
$11.9M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Race/Ethnicity and Mammographic Density: Genetic and Lifestyle FactorsK01CA188075 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WARNER, ERICA T · 2014 to 2017
$518k
GWAS on childhood body fatness as an intermediate phenotype of breast cancerR03CA165131 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI LINDSTROEM, SARA · 2012 to 2013
$174k
NCI NIH HHS K01 CA188075NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA067262NCI NIH HHS R03 CA165131NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

objectiveThis study aimed to uncover genetic contributors to adiposity in early life.

methodsA genome-wide association study of childhood body fatness in 34,401 individuals within the Nurses' Health Studies and the Health Professionals Follow-up Study was conducted. Data were imputed to the 1000 Genomes Phase 3 version 5 reference panel.

resultsA total of 1,354 single-nucleotide polymorphisms (P < 10

conclusionsAdditional loci that contribute to childhood adiposity were identified, further explicating its genetic architecture.

Indexed as

Pediatric ObesityAdiposityAdultAgedBody Mass IndexFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPhenotypePolymorphism, Single NucleotideProspective StudiesYoung Adult

Identifiers

PMID33491310
PMCPMC7842657
OpenAlexW3125895959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.