Evidence map›Paper›PMID 33491231›Full record

ReviewImmunological reviews2021

Transcriptional and epigenetic regulation of memory NK cell responses.

Aimee M Beaulieu

Abstract readReview
In one paragraph

Review in Immunological reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. TNature immunology · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Nutrient transporter pattern in CD56Frontiers in immunology · 2024
    Article
  9. Review
  10. Harnessing the power of memory-like NK cells to fight cancer.Clinical and experimental immunology · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Aimee M BeaulieuCenter for Immunity and Inflammation, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers - The State University of New Jersey, Newark, NJ, USA.ORCID 0000-0002-7301-0002

Funding

Innate Immune Mechanisms at the Maternal-Fetal Interface in Normal and Superovulatory PregnancyR01AI148695 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI BEAULIEU, AIMEE MELISSA, DOUGLAS, NATAKI C · 2019 to 2023
$3.8M
Birc5 as a regulator of NK cell development and immune functionR01HL139818 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI BEAULIEU, AIMEE MELISSA · 2019 to 2023
$1.9M
NHLBI NIH HHS R01 HL139818NIAID NIH HHS R01 AI148695NIH-NHLBI R01HL139818NIH-NIAID R01AI148695
6 · The paper itself

Abstract

Natural killer (NK) cells are cytotoxic innate lymphocytes with key roles in host protection against viruses and malignancy. Notwithstanding their historical classification as innate immune cells, NK cells are now understood to have some capacity to mount memory or memory-like immune responses in which effector cells undergo antigen-driven expansion and give rise to long-lived memory cells with enhanced functionality. Understanding how antigen-specific effector and memory NK responses are regulated is an important and active area of research in the field. Here, we discuss key transcription factors and epigenetic processes involved in antigen-specific effector and memory NK cell differentiation.

Indexed as

Epigenesis, GeneticImmunologic MemoryAntigensKiller Cells, NaturalLymphocyte ActivationAntigensepigeneticmemorynatural killerNK celltranscription factors

Identifiers

PMID33491231
PMCPMC8726596

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.