Evidence map›Paper›PMID 33490977›Full record

ArticleSTAR protocols2021

A protocol for rapid pericyte differentiation of human induced pluripotent stem cells.

Elizabeth A Aisenbrey, Elizabeth Torr, Hunter Johnson, Cheryl Soref, William Daly, William L Murphy

Abstract read
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Advances in human induced pluripotent stem cell (hiPSC)-based disease modelling in cardiogenetics.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
  6. Review
  7. Review
  8. Experimental laboratory models as tools for understanding modifiable dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. Merits and challenges of iPSC-derived organoids for clinical applications.Frontiers in cell and developmental biology · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth A AisenbreyDepartment of Surgery, University of Wisconsin, Madison, WI 53705, USA.
Elizabeth TorrDepartment of Orthopedics, University of Wisconsin, Madison, WI 53705, USA.
Hunter JohnsonDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI 53705, USA.
Cheryl SorefWaisman Center, University of Wisconsin, Madison, WI 53705, USA.
William DalyDepartment of Orthopedics, University of Wisconsin, Madison, WI 53705, USA.
William L MurphyDepartment of Orthopedics, University of Wisconsin, Madison, WI 53705, USA.

Funding

Harnessing human brain and liver microphysiological systems for testing therapeutics for metastatic melanomaU01TR002383 · NCATS · VANDERBILT UNIVERSITY · PI MURPHY, WILLIAM L., TAYLOR, D. LANSING · 2018 to 2022
$7.6M
A Neurovascular Microphysiological SystemR01NS109427 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI MURPHY, WILLIAM L. · 2019 to 2023
$1.7M
NCATS NIH HHS U01 TR002383NINDS NIH HHS R01 NS109427
6 · The paper itself

Abstract

Pericytes play a critical role in promoting, regulating, and maintaining numerous vascular functions. Their dysfunction is a major contributor to the progression of vascular and neurodegenerative diseases, making them an ideal candidate for large-scale production for disease modeling and regenerative cell therapy. This protocol describes the rapid and robust differentiation of pericytes from human induced pluripotent stem cells (hiPSCs) while simultaneously generating a population of hiPSC-derived endothelial progenitor cells. For complete details on the use and execution of this protocol, please refer to Zhang et al. (2017).

Indexed as

Cell Culture TechniquesCell DifferentiationHumansInduced Pluripotent Stem CellsPericytesCell differentiationStem cells

Identifiers

PMID33490977
PMCPMC7811164

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.