Evidence map›Paper›PMID 33490916›Full record

ReviewiScience2021

Targeting implant-associated infections: titanium surface loaded with antimicrobial.

João Gabriel Silva Souza, Martinna Mendonça Bertolini, Raphael Cavalcante Costa, Bruna Egumi Nagay, Anna Dongari-Bagtzoglou, Valentim Adelino Ricardo Barão

Abstract readReview
In one paragraph

Review in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

João Gabriel Silva SouzaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, Brazil.
Martinna Mendonça BertoliniDepartment of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA.
Raphael Cavalcante CostaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, Brazil.
Bruna Egumi NagayDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, Brazil.
Anna Dongari-BagtzoglouDepartment of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA.
Valentim Adelino Ricardo BarãoDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, Brazil.

Funding

Oral Epithelial Cells, Candida and PMN ActivationR01DE013986 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Anna I Dongari-Bagtzoglou · 2000 to 2026
$9.2M
Control of heterogeneous microbial communities using model-based multi-objective optimizationR01GM127909 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DONGARI-BAGTZOGLOU, ANNA I, LAUBENBACHER, REINHARD · 2018 to 2021
$1.8M
NIDCR NIH HHS R01 DE013986NIGMS NIH HHS R01 GM127909
6 · The paper itself

Abstract

Implant devices have = proven a successful treatment modality in reconstructive surgeries. However, increasing rates of peri-implant diseases demand further examination of their pathogenesis. Polymicrobial biofilm formation on titanium surfaces has been considered the main risk factor for inflammatory processes on tissues surrounding implant devices, which often lead to implant failure. To overcome microbial accumulation on titanium surfaces biofilm targeting strategies have been developed to modify the surface and incorporate antimicrobial coatings. Because antibiotics are widely used to treat polymicrobial infections, these agents have recently started to be incorporated on titanium surface. This review discusses the biofilm formation on titanium dental implants and key factors to be considered in therapeutic and preventative strategies. Moreover, a systematic review was conducted on coatings developed for titanium surfaces using different antibiotics. This review will also shed light on potential alternative strategies aiming to reduce microbial loads and control polymicrobial infection on implanted devices.

Indexed as

MicrobiofilmsSurface Science

Identifiers

PMID33490916
PMCPMC7811145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.