Evidence map›Paper›PMID 33490913›Full record

ArticleiScience2021

Disproportionate presence of adenosine in mitochondrial and chloroplast DNA of

Waleed M M El-Sayed, Alli L Gombolay, Penghao Xu, Taehwan Yang, Youngkyu Jeon, Sathya Balachander, Gary Newnam, Sijia Tao, Nicole E Bowen, Tomáš Brůna and 5 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Ribonucleotide errors, RNase HII, and ribonucleotide excision repair.Critical reviews in biochemistry and molecular biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Waleed M M El-SayedSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Alli L GombolaySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Penghao XuSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Taehwan YangSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Youngkyu JeonSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Sathya BalachanderSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Gary NewnamSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Sijia TaoDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30309, USA.
Nicole E BowenDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30309, USA.
Tomáš BrůnaSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Mark BorodovskySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Raymond F SchinaziDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30309, USA.
Baek KimDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30309, USA.
Yongsheng ChenSchool of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Francesca StoriciSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Georgia Institute of Technology · USEmory University · US

Funding

Lentivirus Replication Strategy and PathogenesisR01AI136581 · NIAID · EMORY UNIVERSITY · PI Baek Kim · 2018 to 2026
$3.9M
Towards Suppression and Elimination of HIV in the CNSR01MH116695 · NIMH · EMORY UNIVERSITY · PI SCHINAZI, RAYMOND FELIX, TYOR, WILLIAM R · 2018 to 2022
$3.4M
Ribose-seq profile and analysis of ribonucleotides in DNA of oxidatively-stressed and cancer cellsR01ES026243 · NIEHS · GEORGIA INSTITUTE OF TECHNOLOGY · PI STORICI, FRANCESCA · 2016 to 2020
$1.4M
NIGMS Administrative Supplements to Support Undergraduate Summer ResearchR01GM128145 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI BORODOVSKY, MARK · 2018 to 2021
$1.1M
SAMHD1 controls dNTP pool and HIV sensitivity to NRTIsR01AI150451 · NIAID · EMORY UNIVERSITY · PI KIM, BAEK · 2019 to 2019
$311k
NIAID NIH HHS R01 AI136581NIAID NIH HHS R01 AI150451NIEHS NIH HHS R01 ES026243NIGMS NIH HHS R01 GM128145NIMH NIH HHS R01 MH116695
6 · The paper itself

Abstract

Ribonucleoside monophosphates (rNMPs) represent the most common non-standard nucleotides found in the genome of cells. The distribution of rNMPs in DNA has been studied only in limited genomes. Using the ribose-seq protocol and the Ribose-Map bioinformatics toolkit, we reveal the distribution of rNMPs incorporated into the whole genome of a photosynthetic unicellular green alga,

Indexed as

GenomicsMolecular Biology

Identifiers

PMID33490913
PMCPMC7809514
OpenAlexW3113919055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.