Evidence map›Paper›PMID 33490882›Full record

ArticleFASEB bioAdvances2021

Dexamethasone acutely suppresses the anabolic SNAT2/SLC38A2 amino acid transporter protein in L6-G8C5 rat skeletal muscle cells.

Safia Blbas, Emma Watson, Heather Butler, Jeremy Brown, Terence P Herbert, Cordula M Stover, Alan Bevington, Nima Abbasian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB bioAdvances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Safia BlbasDepartment of Respiratory Sciences University of Leicester Leicester UK.
Emma WatsonDepartment of Cardiovascular Sciences University of Leicester Leicester UK.
Heather ButlerJohn Walls Renal Unit University Hospitals of Leicester Leicester UK.
Jeremy BrownDepartment of Cardiovascular Sciences University of Leicester Leicester UK.
Terence P HerbertSchool of Pharmacy University of Lincoln Lincoln UK.
Cordula M StoverDepartment of Respiratory Sciences University of Leicester Leicester UK.
Alan BevingtonDepartment of Respiratory Sciences University of Leicester Leicester UK.
Nima AbbasianDepartment of Respiratory Sciences University of Leicester Leicester UK.ORCID https://orcid.org/0000-0002-6906-2563
University of Leicester · GBLeicester General Hospital · GBUniversity of Lincoln · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic metabolic acidosis plays a role in cachexia by enhancing total proteolysis in skeletal muscle. Glucocorticoid also triggers proteolysis and plays a permissive role in the effect of acidosis. The System A amino acid transporter SNAT2/SLC38A2 is ubiquitously expressed in mammalian cells including muscle, performing Na

Indexed as

dexamethasoneglucocorticoidskeletal muscleSLC38A2SNAT2ubiquitin‐proteasome pathway

Identifiers

PMID33490882
PMCPMC7805547
OpenAlexW3092076894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.