Evidence map›Paper›PMID 33490635›Full record

ReviewHealth science reports2021

How to prevent ROP in preterm infants in Indonesia?

Johanes Edy Siswanto, Peter H Dijk, Arend F Bos, Rita S Sitorus, Asri C Adisasmita, Sudarto Ronoatmodjo, Pieter J J Sauer

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Health science reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Johanes Edy SiswantoNeonatology Working Group, Department of Pediatrics Harapan Kita Women and Children Hospital Jakarta Indonesia.ORCID https://orcid.org/0000-0002-6209-9312
Peter H DijkDepartment of Pediatrics Beatrix Children's Hospital, University Medical Center Groningen Groningen The Netherlands.
Arend F BosDepartment of Pediatrics Beatrix Children's Hospital, University Medical Center Groningen Groningen The Netherlands.
Rita S SitorusDepartment of Ophthalmology Cipto Mangunkusumo Hospital Jakarta Indonesia.
Asri C AdisasmitaDepartment of Epidemiology University of Indonesia, School of Public Health Depok Indonesia.
Sudarto RonoatmodjoDepartment of Epidemiology University of Indonesia, School of Public Health Depok Indonesia.
Pieter J J SauerDepartment of Pediatrics Beatrix Children's Hospital, University Medical Center Groningen Groningen The Netherlands.
University Medical Center Groningen · NLUniversity of Indonesia · IDPelita Harapan University · IDRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsRetinopathy of prematurity (ROP) is a severe disease in preterm infants. It is seen more frequently in Low-Middle Income Countries (LMIC) like Indonesia compared to High-Income Countries (HIC). Risk factors for ROP development are -extreme- preterm birth, use of oxygen, neonatal infections, respiratory problems, inadequate nutrition, and blood and exchange transfusions. In this paper, we give an overview of steps that can be taken in LMIC to prevent ROP and provide guidelines for screening and treating ROP.

methodsBased on the literature search and data obtained by us in Indonesia's studies, we propose guidelines for the prevention, screening, and treatment of ROP in preterm infants in LMIC.

resultsPrevention of ROP starts before birth with preventing preterm labor, transferring a mother who might deliver <32 weeks to a perinatal center and giving corticosteroids to mothers that might deliver <34 weeks. Newborn resuscitation must be done using room air or, in the case of very preterm infants (<29-32 weeks) by using 30% oxygen. Respiratory problems must be prevented by starting continuous positive airway pressure (CPAP) in all preterm infants <32 weeks and in case of respiratory problems in more mature infants. If needed, the surfactant should be given in a minimally invasive manner, as ROP's lower incidence was found using this technique. The use of oxygen must be strictly regulated with a saturation monitor of 91-95%. Infections must be prevented as much as possible. Both oral and parenteral nutrition should be started in all preterm infants on day one of life with preferably mothers' milk. Blood transfusions can be prevented by reducing the amount of blood needed for laboratory analysis. DISCUSSION: Preterm babies should be born in facilities able to care for them optimally. The use of oxygen must be strictly regulated. ROP screening is mandatory in infants born <34 weeks, and infants who received supplemental oxygen for a prolonged period. In case of progression of ROP, immediate mandatory treatment is required.

conclusionConcerted action is needed to reduce the incidence of ROP in LMIC. "STOP - R1O2P3" is an acronym that can help implement standard practices in all neonatal intensive care units in LMIC to prevent development and progression.

Indexed as

low‐middle income countriespredisposing factorsrecommendationROPscreening

Identifiers

PMID33490635
PMCPMC7813016
OpenAlexW3123754611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.