Evidence map›Paper›PMID 33490617›Full record

ArticleJGH open : an open access journal of gastroenterology and hepatology2021

Presence and type of decompensation affects outcomes in autoimmune hepatitis upon treatment with corticosteroids.

Sanchit Sharma, Samagra Agarwal, Kanav Kaushal, Abhinav Anand, Deepak Gunjan, Rajni Yadav, Anoop Saraya

Open access · goldAbstract read
In one paragraph

Article in JGH open : an open access journal of gastroenterology and hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Autoimmmune hepatitis.Cellular & molecular immunology · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sanchit SharmaDepartment of Gastroenterology and Human Nutrition All India Institute of Medical Sciences New Delhi India.
Samagra AgarwalDepartment of Gastroenterology and Human Nutrition All India Institute of Medical Sciences New Delhi India.
Kanav KaushalDepartment of Gastroenterology and Human Nutrition All India Institute of Medical Sciences New Delhi India.
Abhinav AnandDepartment of Gastroenterology and Human Nutrition All India Institute of Medical Sciences New Delhi India.
Deepak GunjanDepartment of Gastroenterology and Human Nutrition All India Institute of Medical Sciences New Delhi India.
Rajni YadavDepartment of Pathology All India Institute of Medical Sciences New Delhi India.
Anoop SarayaDepartment of Gastroenterology and Human Nutrition All India Institute of Medical Sciences New Delhi India.ORCID https://orcid.org/0000-0002-3921-6752
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsDecompensated cirrhosis in autoimmune hepatitis has poor prognosis. Besides liver transplant, treatment for this entity is undefined. We explored the outcomes of autoimmune hepatitis (AIH)-related decompensated cirrhosis with active disease on treatment with steroids.

methodsIn this retrospective analysis, clinical data, laboratory parameters, and prognostic scores, such as baseline model for end-stage liver disease (MELD) scores, were compared among patients of AIH with decompensated cirrhosis with mild/no ascites (

resultsSteroids were initiated at lower doses (25 mg/day-mild/no ascites, 20 mg/day-gross ascites) in patients with decompensated cirrhosis and at 40 mg/day in those with compensated cirrhosis. Transplant-free survival was 25.4%, 74.6%, and 96.9% (

conclusionType and severity of decompensation affect outcomes in patients with AIH-related cirrhosis. Those with mild/no ascites have comparable outcomes to those with compensated cirrhosis upon treatment with low-dose steroids.

Indexed as

ascitesautoimmune hepatitisportal hypertension

Identifiers

PMID33490617
PMCPMC7812520
OpenAlexW3099135021

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.