Evidence map›Paper›PMID 33490603›Full record

ArticleBMJ open ophthalmology2021

Comparison of the intraocular pressure following an intravitreal triamcinolone acetonide injection for diabetic macula oedema in vitrectomised and non-vitrectomised eyes.

Yusuke Orii, Makoto Gozawa, Yoshihiro Takamura, Yuko Takeuchi, Masakazu Morioka, Yutaka Yamada, Takehiro Matsumura, Masahiko Sugimoto, Masaru Inatani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yusuke OriiDepartment of Ophthalmology, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Japan.ORCID 0000-0002-6246-8106
Makoto GozawaDepartment of Ophthalmology, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Japan.
Yoshihiro TakamuraDepartment of Ophthalmology, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Japan.
Yuko TakeuchiDepartment of Ophthalmology, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Japan.
Masakazu MoriokaDepartment of Ophthalmology, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Japan.
Yutaka YamadaDepartment of Ophthalmology, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Japan.ORCID 0000-0001-7117-1673
Takehiro MatsumuraOphthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan.
Masahiko SugimotoDepartment of Ophthalmology, Mie University, Tsu, Mie, Japan.
Masaru InataniDepartment of Ophthalmology, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Japan.
University of Fukui · JPMie University · JPTokyo Dental College Ichikawa General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the intraocular pressure (IOP) after an intravitreal triamcinolone acetonide (IVTA) between vitrectomised and non-vitrectomised eyes in patients with diabetes and diabetic macular oedema (DME).

designRetrospective comparative study.

methodsMedical records of 157 patients (157 eyes) with type 2 diabetes who received IVTA for DME were reviewed, and the best-corrected visual acuity, IOP and optical central retinal thickness (CRT) were compared preoperatively, at 1, 4, 12 and 24 weeks after IVTA between the vitrectomised and non-vitrectomised groups.

resultsIOP significantly increased at 1 (p<0.0001), 4 (p<0.0001), 8 (p<0.0001), 12 (p=0.0019), 16 (p=0.0006) and 20 weeks (p=0.0191) in the non-vitrectomised group, whereas a significant increase was only observed at 1 (p=0.0003) and 4 weeks (p=0.0006) in the vitrectomised group. ΔIOP, IOP changes from baseline, in the non-vitrectomised group was significantly higher than that in the vitrectomised group at 4 (p=0.0014), 8 (p=0.0081), 12 (p=0.0032) and 16 weeks (p=0.0038). No significant difference was observed in logMAR and CRT at any time point after IVTA between the two groups.

conclusionsAfter an initial IVTA, increased IOP and ΔIOP from the baseline IOP were significantly more frequently observed in the non-vitrectomised than that in the vitrectomised group. IVTA is a safer and more effective treatment option for DME in vitrectomised than that in non-vitrectomised eyes.

Indexed as

treatment medical

Identifiers

PMID33490603
PMCPMC7798713
OpenAlexW3118916717

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.