Evidence map›Paper›PMID 33490363›Full record

ArticleInternational journal of cardiology. Heart & vasculature2021

Atrial fibrillation after orthotopic heart transplantatation: Pathophysiology and clinical impact.

Sonia Ferretto, Immacolata Giuliani, Tiziana Sanavia, Tomaso Bottio, Angela Pompea Fraiese, Antonio Gambino, Vincenzo Tarzia, Giuseppe Toscano, Sabino Iliceto, Gino Gerosa and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Management of Post-heart Transplant Atrial Fibrillation.Arrhythmia & electrophysiology review · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Impact of atrial fibrillation in heart transplant recipients.International journal of cardiology. Heart & vasculature · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sonia FerrettoDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Immacolata GiulianiIntensive Care and Pain Management Unit, University of Verona, Verona, Italy.
Tiziana SanaviaDepartment of Medical Sciences, University of Torino, Torino, Italy.
Tomaso BottioDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Angela Pompea FraieseDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Antonio GambinoDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Vincenzo TarziaDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Giuseppe ToscanoDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Sabino IlicetoDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Gino GerosaDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Loira LeoniDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
University of Padua · ITUniversity of Turin · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is a well-established post-cardiac surgery complication. Orthotopic heart transplantation (OHT) represents a peculiar condition where surgical thoracic veins isolation and autonomic denervation occur. This study aims at investigating AF incidence in OHT in order to define its risk factors and to evaluate its prognostic impact.

methods278 patients affected by OHT were recruited in our Cardiac Surgery Unit and retrospectively analyzed, using clinical, surgical and instrumental data.

resultsThe patients cohort showed 45 post-operative (16.5%) and 20 late AF cases (7.2%). Only paroxysmal AF episodes were observed. Elderly donors and acute rejection resulted as risk factors in patients with post-operative AF episodes, who presented higher all-cause mortality at 11 years post-OHT (p < 0.001, Kaplan Meier analysis). The majority of late AF episodes occurred during hospitalization, due to renal failure or infections and more frequently in male patients; no significant correlation was observed with acute or chronic rejection or other characteristics.

conclusionPulmonary vein isolation and vagal denervation lead to low AF incidence in OHT recipients. Acute rejection and graft status are the main risk factors for post-operative AF episodes, while other systemic conditions act as late AF triggers. The occurrence of AF episodes is associated with poor outcome and AF should be considered as a marker of clinical frailty.

Indexed as

Atrial fibrillationHeart failureHeart recipientHeart transplantation

Identifiers

PMID33490363
PMCPMC7811113
OpenAlexW3119100687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.