Evidence map›Paper›PMID 33490361›Full record

ReviewAlzheimer's & dementia (New York, N. Y.)2020

Frontotemporal dementia and COVID-19: Hypothesis generation and roadmap for future research.

Kok Pin Ng, Hui Jin Chiew, Shahul Hameed, Simon Kang Seng Ting, Adeline Ng, See Ann Soo, Benjamin Y X Wong, Levinia Lim, Alisa C W Yong, Vincent C T Mok and 8 more

Open access · goldAbstract readReview
In one paragraph

Review in Alzheimer's & dementia (New York, N. Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Extracellular Vesicles: The Invisible Heroes and Villains of COVID-19 Central Neuropathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 8 countries.

Kok Pin NgDepartment of Neurology National Neuroscience Institute Singapore Singapore.
Hui Jin ChiewDepartment of Neurology National Neuroscience Institute Singapore Singapore.
Shahul HameedDepartment of Neurology National Neuroscience Institute Singapore Singapore.
Simon Kang Seng TingDepartment of Neurology National Neuroscience Institute Singapore Singapore.
Adeline NgDepartment of Neurology National Neuroscience Institute Singapore Singapore.
See Ann SooDepartment of Neurology National Neuroscience Institute Singapore Singapore.
Benjamin Y X WongDepartment of Neurology National Neuroscience Institute Singapore Singapore.
Levinia LimDepartment of Neurology National Neuroscience Institute Singapore Singapore.
Alisa C W YongDepartment of Neurology National Neuroscience Institute Singapore Singapore.
Vincent C T MokGerald Choa Neuroscience Centre Lui Che Woo Institute of Innovative Medicine Department of Medicine and Therapeutics Prince of Wales Hospital Faculty of Medicine The Chinese University of Hong Kong Shatin New Territories Hong Kong SAR China.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Alzheimer's Disease Research Unit Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics McGill University Montreal Canada.
Jacqueline DominguezSt. Luke's Medical Center Institute for Neurosciences Metro Manila Philippines.
SangYun KimDepartment of Neurology Seoul National University College of Medicine and Clinical Neuroscience Center of Seoul National University Bundang Hospital Seongnam-si Korea.
G Y Robin HsiungDepartment of Medicine University of British Columbia Vancouver British Columbia Canada.
Manabu IkedaDepartment of Psychiatry Graduate School of Medicine, Osaka University Osaka Japan.
Bruce L MillerMemory and Aging Center Department of Neurology University of California San Francisco San Francisco California USA.
Serge GauthierTranslational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Alzheimer's Disease Research Unit Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics McGill University Montreal Canada.
Nagaendran KandiahDepartment of Neurology National Neuroscience Institute Singapore Singapore.ORCID https://orcid.org/0000-0001-9244-4298
Nanyang Technological University · SGNational Neuroscience Institute · SGDouglas Mental Health University Institute · CAChinese University of Hong Kong · HKOsaka University of Economics · JPSeoul National University Bundang Hospital · KRSt. Luke's Medical Center · PHUniversity of British Columbia · CAUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has caused tremendous suffering for patients with dementia and their caregivers. We conducted a survey to study the impact of the pandemic on patients with mild frontotemporal dementia (FTD). Our preliminary findings demonstrate that patients with FTD have significant worsening in behavior and social cognition, as well as suffer greater negative consequences from disruption to health-care services compared to patients with AD. The reduced ability to cope with sudden changes to social environments places patients with FTD at increased vulnerability to COVID-19 infection as well as to poorer clinical and social outcomes. Caregivers of FTD patients also demonstrate high burden during crisis situations. A proportion of patients with FTD benefitted from use of web-based interactive platforms. In this article, we outline the priority areas for research as well as a roadmap for future collaborative research to ensure greatest benefit for patients with FTD and their caregivers.

Indexed as

COVID‐19frontotemporal dementiaresearch roadmap

Identifiers

PMID33490361
PMCPMC7810128
OpenAlexW3119316063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.