ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Patterns of glucose hypometabolism in Down syndrome resemble sporadic Alzheimer's disease except for the putamen.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Intracerebral age-independent reduction of endothelium-dependent hyperpolarization and nitric oxide signalling in the Dp16 mouse model of Down syndrome.The Journal of physiology · 2026Article
- Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease.Annals of neurology · 2025Article
- Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.Brain communications · 2024Article
- Characterizing the emergence of amyloid and tau burden in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cocaine perturbs mitovesicle biology in the brain.Journal of extracellular vesicles · 2023Article
- Review
- Multi-Modal Neuroimaging Neural Network-Based Feature Detection for Diagnosis of Alzheimer's Disease.Frontiers in aging neuroscience · 2022Article
- White matter microstructure associations to amyloid burden in adults with Down syndrome.NeuroImage. Clinical · 2022Article
- Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Review
- Patterns of glucose hypometabolism in Down syndrome resemble sporadic Alzheimer's disease except for the putamen.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionAdults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and the relationship between cognition and glucose metabolism in this population has yet to be evaluated.
methodsAdults with DS (N = 90; mean age [standard deviation] = 38.0 [8.30] years) underwent [C-11]Pittsburgh compound B (PiB) and [F-18]fluorodeoxyglucose (FDG) positron emission tomography scans. Associations among amyloid beta (Aβ), FDG, and measures of cognition were explored. Interregional FDG metabolic connectivity was assessed to compare cognitively stable DS and mild cognitive impairment/AD (MCI-DS/AD).
resultsNegative associations between Aβ and FDG were evident in regions affected in sporadic AD. A positive association was observed in the putamen, which is the brain region showing the earliest increases in Aβ deposition. Both Aβ and FDG were associated with measures of cognition, and metabolic connectivity distinguished cases of MCI-DS/AD from cognitively stable DS. DISCUSSION: Associations among Aβ, FDG, and cognition reveal that neurodegeneration in DS resembles sporadic AD with the exception of the putamen, highlighting the usefulness of FDG in monitoring neurodegeneration in DS.
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