Evidence map›Paper›PMID 33490355›Full record

ArticleGynecologic oncology reports2021

Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case report.

Sandra Deac, Mihaela Marioara Stana, Andrei Dan Havasi, Calin Cainap, Anca-Raluca Popita, Ana Maria Bordeianu, Simona Cainap, Madalina Bota, Ovidiu Vasile Bochis

Open access · goldAbstract readCase Reports
In one paragraph

Article in Gynecologic oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sandra DeacOncology Institute "Ion Chiricuta", Medical Oncology Department, Cluj Napoca, Romania.
Mihaela Marioara StanaOncology Institute "Ion Chiricuta", Medical Oncology Department, Cluj Napoca, Romania.
Andrei Dan HavasiOncology Institute "Ion Chiricuta", Medical Oncology Department, Cluj Napoca, Romania.
Calin CainapOncology Institute "Ion Chiricuta", Medical Oncology Department, Cluj Napoca, Romania.
Anca-Raluca PopitaOncology Institute "Ion Chiricuta", Radiology and Medical Imaging Department, Cluj Napoca, Romania.
Ana Maria BordeianuRoNEURO Institute, Cluj-Napoca, Romania.
Simona CainapDepartment of Mother and Child, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj Napoca, Romania.
Madalina BotaDepartment of Mother and Child, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj Napoca, Romania.
Ovidiu Vasile BochisOncology Institute "Ion Chiricuta", Medical Oncology Department, Cluj Napoca, Romania.
Institute of Oncology Prof. Dr. Ion Chiricuta · ROIuliu Hațieganu University of Medicine and Pharmacy · ROResearch Institute for Analytical Instrumentation · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraneoplastic neurologic syndromes (PNS) are a rare heterogeneous group of disorders associated with malignancy that can result in significant functional impairment. One syndrome in particular, paraneoplastic cerebellar degeneration (PCD), may be severely disabling. PCD is a rare neurological syndrome, associated with active or subclinical cancer, characterized by acute or subacute onset cerebellar ataxia due to tumor-induced autoimmunity against cerebellar antigens. Treatment of paraneoplastic syndromes is generally unsatisfactory, but early diagnosis and treatment of PCD, which includes neurological treatment, immunotherapy and oncological treatment of associated malignancy, may improve the neurological prognosis. We reported the case of a 59-year-old woman who presented PCD as the first sign of ovarian cancer. Laboratory investigations showed the presence of anti-Yo antibodies in the serum. The brain MRI revealed specific modifications for PCD. After oncological treatment, intravenous immunoglobulin therapy and corticosteroid therapy, the oncological response was satisfactory, but no improvement of the neurologic symptoms was achieved.

Indexed as

Anti-Yo antibodiesGynecological cancerOvarian cancerParaneoplastic cerebellar degenerationParaneoplastic syndromes

Identifiers

PMID33490355
PMCPMC7808941
OpenAlexW3115400262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.