ReviewPractical laboratory medicine2021
Biological variation: Understanding why it is so important?
Review in Practical laboratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Improving reliability of permanent tooth staging for dental age estimation using the crown-root ratio method.International journal of legal medicine · 2026Article
- Beyond Lesions: Systemic Inflammatory and Metabolic Characterization of Swine Inflammation and Necrosis Syndrome.Animals : an open access journal from MDPI · 2026Article
- Biological Versus Technical Reliability of Epigenetic Clocks and Implications for Disease Prognosis and Intervention Response.Aging cell · 2026Article
- A Bayesian Modeling Approach to Optimize Longitudinal Biomarker Sampling Schedules Using Hormonal Data.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Metrology in Bioelectrical Impedance Analysis (BIA): From Measurement Science to Clinical and Research Applications.Sensors (Basel, Switzerland) · 2026Review
- Interpretation of Chemistry, Hematology and Coagulation Laboratory Results in Early-Phase Clinical Pharmacology Trials; a Retrospective Analysis Based on the Placebo Arm of Randomized-Controlled Trials.Clinical and translational science · 2026Article
- A nonparametric statistical method for deconvolving densities in the analysis of proteomic data.BMC bioinformatics · 2026Article
- Article
- Potential benefits of an alternative haemoglobin deferral strategy evaluated in seven countries.Vox sanguinis · 2026Article
- The impact of pathological fluctuations versus biological variation on the interpretation of laboratory values.Practical laboratory medicine · 2025Article
- Calibration Error, a Neglected Error Source in the Clinical Laboratory Quality Control.EJIFCC · 2025Article
- Patient-based pre-classified real-time quality control with neural network (PCRTQC-NN).Practical laboratory medicine · 2025Article
- CrossLabFit: A novel framework for integrating qualitative and quantitative data across multiple labs for model calibration.PLoS computational biology · 2025Article
- The individuality of plantar pressure indices enables the reduction of descriptive gait data required for diagnostic purposes.Scientific reports · 2025Article
- Multiplexed Quantification of First-Trimester Serum Biomarkers in Healthy Pregnancy.International journal of molecular sciences · 2025Article
- Predicting Anabolic Androgenic Steroid Doping among Specialized Health Care Patients with Elastic Net Regression Reveals Potential Laboratory Variables for "Patient Biological Passport".Sports medicine - open · 2025Article
- Therapeutic strategies to reverse cigarette smoke-induced ion channel and mucociliary dysfunction in COPD airway epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- What's in a number: Falling on the sword of cut-off points and reference limits?Journal of the colleges of medicine of South Africa · 2025Article
- Biological variation of capillary blood glucose: A systematic review.Biomedical reports · 2025Article
- Using the Constrained Disorder Principle to Navigate Uncertainties in Biology and Medicine: Refining Fuzzy Algorithms.Biology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This Review will describe the increasing importance of the concepts of biological variation to clinical chemists. The idea of comparison to 'reference' is fundamental in measurement. For the biological measurands, that reference is the relevant patient population, a clinical decision point based on a trial or an individual patient's previous results. The idea of using biological variation to set quality goals was then realised for setting Quality Control (QC) and External Quality Assurance (EQA) limits. The current phase of BV integration into practice is using Patient-Based Real-Time Quality Control (PBRTQC) and Patient Based Quality Assurance (PBQA) to detect a change in assay performance. The challenge of personalised medicine is to determine an individual reference interval. The Athletes Biological Passport may provide the solution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.