Evidence map›Paper›PMID 33490317›Full record

ArticleNeurobiology of stress2021

Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex.

Francisco Javier Pavón, Ilham Y Polis, David G Stouffer, Benjamin F Cravatt, Marisa Roberto, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Loren H Parsons, Antonia Serrano

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Francisco Javier PavónDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Ilham Y PolisDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
David G StoufferDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Benjamin F CravattDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Marisa RobertoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Rémi Martin-FardonDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Fernando Rodríguez de FonsecaUnidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
Loren H ParsonsDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Antonia SerranoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Scripps Research Institute · USHospital Regional Universitario de Málaga · ES

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2003 to 2026
$46.3M
SYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI KOOB, GEORGE F · 1985 to 2002
$5.1M
CHEMOPROTEOMIC METHODS FOR SERINE HYDROLASE INHIBITOR DEVELOPMENTR01DA033760 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F, SCAMPAVIA, LOUIS DANIEL · 2012 to 2021
$5.1M
Regulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7M
Cognitive Function in Alcohol Dependence and Protracted WithdrawalR01AA022249 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARTIN-FARDON, REMI · 2013 to 2017
$2.5M
Pivotal role of thalamic hypocretin transmission during EtOH seeking and relapseR01AA026999 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARTIN-FARDON, REMI · 2018 to 2022
$2.2M
Alcohol dependence and brain endocannabinoid functionR01AA020404 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARTIN-FARDON, REMI · 2011 to 2015
$2.2M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR01AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2009 to 2013
$1.8M
Integrated Acoustic Transfer System for HTS Library ManagementS10OD025279 · OD · SCRIPPS FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2018 to 2018
$624k
Dysregulation of thalamic hypocretin transmission following ethanol dependenceR21AA024146 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARTIN-FARDON, REMI · 2016 to 2017
$505k
HTS Drug  Discovery DispensersS10OD026857 · OD · SCRIPPS FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2019 to 2019
$452k
NIAAA NIH HHS P50 AA006420NIAAA NIH HHS P60 AA006420NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA020404NIAAA NIH HHS R01 AA022249NIAAA NIH HHS R01 AA026999NIAAA NIH HHS R21 AA024146NIAAA NIH HHS R37 AA017447NIDA NIH HHS R01 DA033760NIH HHS S10 OD025279NIH HHS S10 OD026857
6 · The paper itself

Abstract

The endocannabinoid system is involved in the regulation of the stress response, but the relative contribution of N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) and their mechanisms have to be elucidated. In this study, we compared the effects of the pharmacological inhibition of the two major endocannabinoid-degrading enzymes [fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) for AEA and 2-AG, respectively] on stress-coping [forced swim test (FST) and tail suspension test (TST)] and anxiety-like [elevated-plus maze (EPM) and light-dark test (LDT)] behaviors in wild-type and FAAH knockout mice.

Indexed as

2-ArachidonoylglycerolDopamineMicrodialysisMouseStress-coping behavior

Identifiers

PMID33490317
PMCPMC7809503
OpenAlexW3119607664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.