Evidence map›Paper›PMID 33489948›Full record

ArticleGerms2020

Improving the diagnosis of pulmonary tuberculosis using line probe assay and determining the factors associated with the disease in children in Jos, Nigeria.

Augustine O Ebonyi, Stephen Oguche, Ibrahim I Abok, Yetunde O Isa, Charles C Ani, Helen O Akhiwu, Marcia M Ihekaike, Esther S Yiltok, Martha O Ochoga, Atiene S Sagay

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Germs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Augustine O EbonyiMBBS, MSc, Department of Paediatrics, University of Jos and Department of Paediatrics, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria.
Stephen OgucheBMBCh, Department of Paediatrics, University of Jos and Department of Paediatrics, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria.
Ibrahim I AbokMBBS, Department of Paediatrics, University of Jos and Department of Paediatrics, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria.
Yetunde O IsaBMLS, MSc, MPH, APIN Laboratory, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria.
Charles C AniMBBS, Department of Radiology, University of Jos and Department of Radiology, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria.
Helen O AkhiwuMBBS, Department of Paediatrics, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria.
Marcia M IhekaikeMBBS, Faith Alive Foundation Hospital, P. O. Box 745, Jos, Nigeria.
Esther S YiltokMBBS, MEd, Department of Paediatrics, University of Jos and Department of Paediatrics, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria.
Martha O OchogaBMBCH, Department of Paediatrics, Benue State University, PMB 102119, Makurdi, Nigeria.
Atiene S SagayBSc, MBChB, Department of Obstetrics and Gynaecology, University of Jos and Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria.
University of Jos · NG

Funding

Medical Education Partnership Initiative in NigeriaR24TW008878 · FIC · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI ADEWOLE, ISAAC F, OLALEYE, DAVID OLUFEMI · 2010 to 2015
$9.4M
Support of Training and Mentoring in Nigeria for Academics (STAMINA)D43TW010130 · FIC · UNIVERSITY OF JOS · PI SAGAY, ATIENE SOLOMON · 2015 to 2019
$3.2M
FIC NIH HHS D43 TW010130FIC NIH HHS R24 TW008878
6 · The paper itself

Abstract

introductionDiagnosing tuberculosis (TB), including pulmonary tuberculosis (PTB), in children remains a challenge, partly due to its paucibacillary nature in young children. Data on the use of line probe assay (LPA), on gastric and sputum samples, for diagnosing PTB in children are scarce. We determined the proportion of samples positive for

methodsAn observational study in children aged 6 months-16 years. Gastric and sputum samples were examined by SM and by LPA for MTB using GenoType MTBDR

resultsOut of 103 children with presumptive PTB, 47 had confirmed PTB, 26 unconfirmed PTB and 30 unlikely PTB by LPA. In 67 gastric samples, MTB was identified by SM in 2 (3.0%) compared to 28 (41.8%) by LPA while in 31 sputum samples, MTB was identified by SM in 5 (16.1%) compared to 18 (58.1%) by LPA. The factors associated with pulmonary tuberculosis were an abnormal chest X-ray (adjusted odds ratio (AOR))=12.39 [3.75-40.90], p<0.001), sleeping in the same room with more than three persons (AOR=3.30 [1.23-8.85], p=0.018) and sleeping in a room with none or one window (AOR=2.86 [1.03-7.95], p=0.044).

conclusionsLine probe assay improves the diagnosis of pulmonary TB in children, especially with gastric samples, while an abnormal chest X-ray is a useful adjunct in PTB diagnosis. Avoiding overcrowding and having windows in sleeping rooms are a necessary part of TB prevention.

Indexed as

chest X-raychildrengastric sampleLine probe assaypulmonary tuberculosissmear microscopysputum sample

Identifiers

PMID33489948
PMCPMC7811858
OpenAlexW3122679901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.