Evidence map›Paper›PMID 33489877›Full record

ArticleFrontiers in oncology2020

The Molecular Landscape and Biological Alterations Induced by PRAS40-Knockout in Head and Neck Squamous Cell Carcinoma.

Gang Chen, Zhexuan Li, Changhan Chen, Jiajia Liu, Weiming Zhu, Li She, Huimei Huang, Yuexiang Qin, Guancheng Liu, Juncheng Wang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  4. Cognitive Impairment in Multiple Sclerosis.Bioengineering (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Gang ChenDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, China.
Zhexuan LiDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, China.
Changhan ChenDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, China.
Jiajia LiuDepartment of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Weiming ZhuFuzhou Medical College of Nanchang University, Fuzhou, China.
Li SheDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, China.
Huimei HuangDepartment of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Yuexiang QinDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, China.
Guancheng LiuDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, China.
Juncheng WangDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, China.
Yong LiuDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, China.
Donghai HuangDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, China.
Qinglai TangDepartment of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Xin ZhangDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, China.
Gangcai ZhuDepartment of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiangya Hospital Central South University · CNCentral South University · CNNanchang University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PRAS40 (Prolin-rich Akt substrate of 40 kDa) is a critical protein, which directly connects PI3K/Akt and mTORC1 pathway. It plays an indispensable role in the development of various diseases. However, the relationship between PRAS40 and head and neck squamous cell carcinoma (HNSCC) remains unclear. Here, our study indicated that high expression of PRAS40 mRNA is a favorable prognostic factor in HNSCC patients by analyzing 498 clinical and mRNA data. Moreover, we confirmed that CRISPR/Cas9 induced PRAS40-knockout would promote colony formation, cell migration, and invasion in several HNSCC cell lines. RNA-seq was employed to investigate the further possible mechanisms involving the above regulations by PRAS40 in HNSCC cells. The molecular landscape contributed by 253 differentially expressed mRNA after PRAS40-knockout was enriched in TGF-beta, PI3K-Akt, P53, mTOR, NF-

Indexed as

CRISPR/Cas9head and neck squamous cell carcinomaimmunomicro-environmentmetastasisprolin-rich Akt substrate of 40 kDaThe Cancer Genome Atlas

Identifiers

PMID33489877
PMCPMC7821427
OpenAlexW3120576134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.