ArticleBritish journal of cancer1988
Structure and expression of c-myc and c-fos proto-oncogenes in thyroid carcinomas.
Article in British journal of cancer, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 85 citations in OpenAlex.
- Targeting transcriptional regulators for treatment of anaplastic thyroid cancer.Journal of cancer metastasis and treatment · 2021Article
- Potentiated anti-tumor effects of BETi by MEKi in anaplastic thyroid cancer.Endocrine-related cancer · 2019Article
- Synergistic effects of BET and MEK inhibitors promote regression of anaplastic thyroid tumors.Oncotarget · 2018Article
- cMYC expression in thyroid follicular cell-derived carcinomas: a role in thyroid tumorigenesis.Diagnostic pathology · 2017Article
- Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin.Scientific reports · 2017Article
- New Treatment Options for Metastatic Thyroid Cancer.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2015Article
- Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue.BMC cancer · 2015Article
- Molecular and other novel advances in treatment of metastatic epithelial and medullary thyroid cancers.Journal of oncology · 2010Article
- Anti-apoptotic effects of protein kinase C-delta and c-fos in cisplatin-treated thyroid cells.British journal of pharmacology · 2009Article
- Medullary thyroid carcinoma: targeted therapies and future directions.Journal of oncology · 2009Article
- Molecular pathobiology of thyroid neoplasms.Endocrine pathology · 2002Review
- Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets.Nucleic acids research · 1997Article
- Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer.Annals of surgical oncology · 1996Article
- c-fos oncogene underexpression in salivary gland tumors as measured by in situ hybridization.The American journal of pathology · 1993Article
- p53 gene mutations associated with anaplastic transformation of human thyroid carcinomas.Japanese journal of cancer research : Gann · 1992Article
- Expression of c-erbB-2 protein in papillary thyroid carcinomas.British journal of cancer · 1992Article
- Thyroid oncology: The end of the dogmas.Endocrine pathology · 1991Article
- The utility of some modern techniques in understanding thyroid pathology.Endocrine pathology · 1990Review
- Detection of the H-RAS oncogene in human thyroid anaplastic carcinomas.Experientia · 1989Article
- Fos-jun and the primary genomic response in the nervous system. Possible physiological role and pathophysiological significance.Molecular neurobiologyReview
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9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumour specimens from 23 patients with thyroid carcinoma, 22 patients with thyroid adenoma, 3 with Graves' disease, and tissues from 8 normal thyroid glands were analyzed by Southern blot hybridization for the physical state of c-myc and c-fos proto-oncogenes. In 4 patients, both the primary tumour and lymph node metastases were analyzed. No amplification or rearrangement of the two proto-oncogenes was detected. Total RNAs were also analyzed. Elevated levels of the 2.4 kb c-myc RNA and of the 2.2 kb c-fos RNA were found in 13/23 (57%) and 14/23 (61%) of the cancer patients, respectively. High levels of c-myc transcripts were more frequently found in thyroid carcinomas with unfavourable prognosis. Concomitant elevated levels of both c-myc and c-fos RNAs were found in 8 cancers. High levels of c-myc RNA were also found in 1 out of 22 specimens of adenoma, in 1 specimen of Graves' disease and in 2 normal thyroid glands. High levels of c-fos RNA were found in 20 of the 22 adenoma samples and in 2 out of 8 normal thyroid tissues. These data indicate that the overexpression of c-myc and c-fos genes is independent of an alteration of the loci. The high levels of c-fos found in adenoma may be associated with the differentiation state of these tumours.
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