Evidence map›Paper›PMID 33489474›Full record

ReviewAmerican journal of clinical and experimental immunology2020

Current concept for tertiary lymphoid structures in urothelial carcinoma of the bladder: a literature review and our experience.

Milena Gulinac, Dorian Dikov, Simeon Lichev, Tsvetelina Velikova

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in American journal of clinical and experimental immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Tertiary lymphoid structures in colorectal cancer - organization and immune cell interactions.American journal of clinical and experimental immunology · 2024
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Milena GulinacDepartment of General and Clinical Pathology, Medical University of Plovdiv Bulgaria.
Dorian DikovGrand Hospital de l'Este Francilien Jossigny, France.
Simeon LichevResident of Medical University of Plovdiv Bulgaria.
Tsvetelina VelikovaDepartment of Clinical Immunology, Medical University of Sofia, Bulgaria/University Hospital Lozenetz Sofia, Bulgaria.
Medical University Plovdiv · BGCentre Hospitalier Sud Francilien · FRLozenetz Hospital · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder carcinoma (BC) is one of the most common malignancies of the urinary system in developed countries, with a high number of recurrences. The secondary lymphoid organs (SLO) are crucial for initiating the adaptive immune response. They are developed as a part of a genetically preprogrammed process during embryogenesis. However, SLO's organogenesis can be reduplicated de novo in other tissues by a process termed lymphoid neo-genesis, giving rise to tertiary lymphoid structures (TLS). These well-organized lymphoid structures in cancer are essential modulators of cancer immunologic response, and the histological examination of TLS gave a new strategy for cancer immunotherapy. This review explores the biological and histological characteristics of TLS in muscle non-invasive and invasive BC.

Indexed as

bladder carcinomaimmunologyimmunotherapyTertiary lymphoid structuresTRLurothelial carcinoma

Identifiers

PMID33489474
PMCPMC7811926
OpenAlexW3122345112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.