Evidence map›Paper›PMID 33489465›Full record

ArticleAmerican journal of stem cells2020

Effect of mesenchymal stem cells injection and low-level laser therapy on bone formation after rapid maxillary expansion: an animal study.

Sadra Mohaghegh, Hossein Mohammad-Rahimi, Ladan Eslamian, Asghar Ebadifar, Mohammad Reza Badiee, Mohammadhossein Farahani, Masoud Mohebbi Rad, Saeed Reza Motamedian

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In one paragraph

Article in American journal of stem cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sadra MohagheghUndergraduate Student, Student Research Committee, School of Dentistry, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Hossein Mohammad-RahimiDental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Ladan EslamianProfessor of Orthodontics, Center of Research & Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Asghar EbadifarAssociated Professor of Orthodontics, Center of Research & Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Mohammad Reza BadieeAssistant Professor of Orthodontics, Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Mohammadhossein FarahaniOrthodontist Arak, Iran.
Masoud Mohebbi RadDental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Saeed Reza MotamedianAssistant Professor of Orthodontics, Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Shahid Beheshti University of Medical Sciences · IRArak University of Medical Sciences · IRResearch Institute for Endocrine Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOne of the most common orthodontic problems is maxillary constriction, which is mostly treated by rapid palatal expansion (RPE). However, its high rate of relapse and prolonged retention period have led to some challenges for orthodontists. To encounter these issues, accelerating bone regeneration can provide long-term stability of expanded maxilla. The present study aimed to evaluate the effect of low-level laser therapy (LLLT), bone marrow-derived mesenchymal stem cells (BMSCs) and their combination on promoting bone regeneration of the inter-maxillary suture after RPE in rats. MATERIALS AND

methodTotal of 60 rats went under RPE treatment. After 7 days, retention period started and interventions (group A, Control (saline); group B, LLLT; group C, BMSCs; group D, LLLT + BMSCs) were performed in the sutural area. After 21 days, radiographic and histological analyses were done. Histological analyses were conducted to evaluate the following criteria of the newly formed bone: the number of osteoblasts, new bone formation, vascularization, connective tissue. Moreover, sutural width was assessed in histologic images. To evaluate bone density at suture area, gray scale and Hounsfield Unit values were measured based on the occlusal radiographic and Micro-Computed topography images respectively.

resultsOnly in group C and D, osteoblasts and new bone formation were observed in all of the samples. There were no significant differences among the study groups regarding the post-treatment sutural width (P > 0.05). In the radiographic analysis, only group D showed more bone density compared to the control group (P = 0.022). Similarly, in micro-CT analysis, the most bone density was observed in group D which was significantly more than the control group (P = 0.013).

conclusionOur findings suggest that the application of LLLT and BMSCs is the most beneficial approach in accelerating bone regeneration in the inter-maxillary suture.

Indexed as

low-level light therapyMesenchymal stem cellsorthodontic treatmentpalatal expansion technique

Identifiers

PMID33489465
PMCPMC7811931
OpenAlexW3124541902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.