Evidence map›Paper›PMID 33489462›Full record

ArticleAmerican journal of cardiovascular disease2020

Correlation of GLUT1 and GLUT4 with prognosis of patients with hypothyroidism and cardiac insufficiency.

Xiaocheng Song, Yudan Zhu, Zhi Dai, Guimei Ling, Hongqin Tang, Qiannan Xu, Tinglin Guo

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cardiovascular disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Endocrine-Metabolic Crosstalk Between Diabetes Mellitus and Hypothyroidism: From Network Mechanisms to Translational Stratification.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025
    Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xiaocheng SongDepartment of Respiratory and Critical Care Medicine, Naval Hospital of Eastern Theater of PLA Zhoushan, Zhejiang Province, China.
Yudan ZhuDepartment of Respiratory and Critical Care Medicine, Naval Hospital of Eastern Theater of PLA Zhoushan, Zhejiang Province, China.
Zhi DaiDepartment of Critical Care Medicine, 921 Hospital of Joint Logistics Support Force of PLA Changsha, Hunan Province, China.
Guimei LingDepartment of Traditional Chinese Medicine, Baise Municipal Hospital Baise, Guangxi Province, China.
Hongqin TangDepartment of Intensive Care Unit, Naval Hospital of Eastern Theater of PLA Zhoushan, Zhejiang Province, China.
Qiannan XuDepartment of Intensive Care Unit, Naval Hospital of Eastern Theater of PLA Zhoushan, Zhejiang Province, China.
Tinglin GuoDepartment of Respiratory and Critical Care Medicine, Naval Hospital of Eastern Theater of PLA Zhoushan, Zhejiang Province, China.
Zhoushan Hospital · CNBaise University · CNHunan Mawangdui Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHypothyroidism is a disease with symptoms of collective metabolic dysfunction and systemic dysfunction due to the lack of serum thyroid hormones caused by various reasons. GLUT4 is over-expressed in monocytes of patients with hyperthyroidism, there are also studies suggesting that there is a certain regulatory relationship of GLUT1 and GLUT4 with thyroid function. This study is aimed to explore the correlation of glucose transporter 1 (GLUT1) and GLUT4 with prognosis of patients with hypothyroidism and cardiac insufficiency.

methodsFrom July 2016 to October 2019, totally 116 patients with cardiac insufficiency complicated with subclinical hypothyroidism treated in our hospital were enrolled in the research group (RG), and 110 patients with cardiac insufficiency but normal thyroid function were enrolled in the control group (CG). Serum GLUT1, GLUT4, free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were detected, and the correlation between them was analyzed. Then the predictive value and risk factors of GLUT1 and GLUT4 for poor prognosis of hypothyroidism complicated with cardiac insufficiency were analyzed.

resultsThe expression levels of GLUT1, GLUT4, FT3 and FT4 in serum of patients in RG was notably lower than that in CG, and TSH expression was remarkably higher than those in CG (P<0.05). In RG, GLUT1 and GLUT4 expression levels were positively correlated with FT3 and FT4 expression (P<0.05), but negatively correlated with TSH expression (P<0.05). ROC of GLUT1 and GLUT4 in RG in predicting poor prognosis of patients was over 0.8. Low expression of GLUT1 and GLUT4 and diabetes were independent risk factors for poor prognosis in patients with hypothyroidism complicated with cardiac insufficiency.

conclusionGLUT1 and GLUT4 expression levels were significantly decreased in serum of patients with hypothyroidism complicated with cardiac insufficiency. Both of them have high predictive value for poor prognosis of patients, and are independent risk factors for poor prognosis of patients.

Indexed as

cardiac insufficiencyGLUT1GLUT4hypothyroidismprognosis prediction

Identifiers

PMID33489462
PMCPMC7811914
OpenAlexW3121471254

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.